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6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.1793-1802

2019

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Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2084-2084

2017

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Abstract CT248: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF- and NRAS-mutation positive solid tumors

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.CT248-CT248

2022

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Abstract LB-005: Allosteric SHP2 phosphatase inhibition: Multiple mechanisms and chemotypes

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.LB-005-LB-005

2019

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Abstract P226: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF mutation positive solid tumors

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P226-P226

2021

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Acidic pH Promotes Refolding and Macroscopic Assembly of Amyloid β (16–22) Peptides at the Air–Water Interface

The journal of physical chemistry letters, 2022-07, Vol.13 (29), p.6674-6679

2022

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Adaptive Entry Guidance for Hypersonic Gliding Vehicles Using Analytic Feedback Control

International Journal of Aerospace Engineering, 2020-11, Vol.2020, p.1-18

2020

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AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway

Oxidative medicine and cellular longevity, 2022-06, Vol.2022, p.1-14

2022

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Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates

International journal of epidemiology, 2013-06, Vol.42 (3), p.816-827

2013

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Aplastic anemia preceding acute lymphoblastic leukemia in an adult with FAT1 mutation

Minerva medica, 2019-12, Vol.110 (6), p.593

2019

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APS Simulation System for 600MW Supercritical Unit Based on Virtual DCS Stimulative Simulator

Intelligent Computing in Smart Grid and Electrical Vehicles, p.296-303

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Artificial liver treatment improves survival in patients with hepatitis B virus‐related acute‐on‐chronic liver failure: A case‐control matched analysis

Hepatology research, 2020-06, Vol.50 (6), p.656-670

2020

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Association of central obesity with hepatocellular carcinoma in patients with chronic hepatitis B receiving antiviral therapy

Alimentary pharmacology & therapeutics, 2021-08, Vol.54 (3), p.329-338

2021

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Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study

Journal of the American Heart Association, 2016-12, Vol.5 (12), p.n/a

2016

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Association of metformin use with cancer incidence and mortality: A meta-analysis

Cancer epidemiology, 2013-06, Vol.37 (3), p.207-218

2013

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The associations of month of birth with body mass index, waist circumference, and leg length: findings from the China Kadoorie Biobank of 0.5 million adults

Journal of epidemiology, 2015, Vol.25 (3), p.221-230

2015

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ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint

Carcinogenesis (New York), 2014-09, Vol.35 (9), p.2007-2013

2014

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AtPHB2 regulates salt stress response in Arabidopsis thaliana

Plant growth regulation, 2021-05, Vol.94 (1), p.23-32

2021

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Basin assemblages and tectonic evolution in the Bohai Gulf and its neighbors

Acta oceanologica Sinica, 2000, Vol.19 (4), p.91-105

2000

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Blocking Adipor1 enhances radiation sensitivity in Hepatoma Carcinoma Cells

Archives of biochemistry and biophysics, 2022-03, Vol.718, p.109152-109152, Article 109152

2022

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Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women

International journal of epidemiology, 2015-08, Vol.44 (4), p.1305-1319

2015

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Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women

Journal of the American Heart Association, 2017-06, Vol.6 (6)

2017

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Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019-03, Vol.1864 (3), p.271-280

2019

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Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization

HPB (Oxford, England), 2020-11, Vol.22 (11), p.1590-1595

2020

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China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

International journal of epidemiology, 2011-12, Vol.40 (6), p.1652-1666

2011

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6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers

Abstract CT248: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF- and NRAS-mutation positive solid tumors

Abstract LB-005: Allosteric SHP2 phosphatase inhibition: Multiple mechanisms and chemotypes

Abstract P226: Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF mutation positive solid tumors

Acidic pH Promotes Refolding and Macroscopic Assembly of Amyloid β (16–22) Peptides at the Air–Water Interface

Adaptive Entry Guidance for Hypersonic Gliding Vehicles Using Analytic Feedback Control

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway

Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates

Aplastic anemia preceding acute lymphoblastic leukemia in an adult with FAT1 mutation

APS Simulation System for 600MW Supercritical Unit Based on Virtual DCS Stimulative Simulator

Artificial liver treatment improves survival in patients with hepatitis B virus‐related acute‐on‐chronic liver failure: A case‐control matched analysis

Association of central obesity with hepatocellular carcinoma in patients with chronic hepatitis B receiving antiviral therapy

Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study

Association of metformin use with cancer incidence and mortality: A meta-analysis

The associations of month of birth with body mass index, waist circumference, and leg length: findings from the China Kadoorie Biobank of 0.5 million adults

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint

AtPHB2 regulates salt stress response in Arabidopsis thaliana

Basin assemblages and tectonic evolution in the Bohai Gulf and its neighbors

Blocking Adipor1 enhances radiation sensitivity in Hepatoma Carcinoma Cells

Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women

Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease

Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

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