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Structural basis for GPR40 allosteric agonism and incretin stimulation

Nature communications, 2018-04, Vol.9 (1), p.1645-11, Article 1645

2018

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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types

Pharmacological research, 2024-03, Vol.201, p.107092-107092, Article 107092

2024

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Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral Nociceptors

Molecular pain, 2007-12, Vol.3 (1), p.38-38

2007

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2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity

Journal of medicinal chemistry, 1999-01, Vol.42 (1), p.50-59

1999

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Novel route to the synthesis of 4-quinolyl isothiocyanates

Tetrahedron letters, 2006-03, Vol.47 (13), p.2161-2164

2006

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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Science translational medicine, 2021-10, Vol.13 (615), p.eabh1486

2021

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The Role of GPR40 (FFAR1) in Pharmacological vs Physiological Control of Incretin Secretion

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines

Molecular cancer therapeutics, 2004-01, Vol.3 (1), p.1-9

2004

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3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

The Journal of neuroscience, 2007-03, Vol.27 (10), p.2718-2726

2007

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A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2- a]pyridine

Tetrahedron, 1999-01, Vol.55 (2), p.541-548

1999

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Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines

Tetrahedron letters, 2002-12, Vol.43 (50), p.9051-9054

2002

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Abstract C129: Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.C129-C129

2023

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A new approach to the asymmetric cyclopropanation via a chiral sulfinyl group

Tetrahedron letters, 1992-03, Vol.33 (13), p.1701-1704

Hamdouchi, Chafiq

1992

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Cloning and functional characterization of the rabbit C-C chemokine receptor 2

BMC immunology, 2005-07, Vol.6 (1), p.15-15, Article 15

2005

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Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1943-1947

2005

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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

Alcohol (Fayetteville, N.Y.), 2009-11, Vol.43 (7), p.491-498

2009

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A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes

Pharmacology research & perspectives, 2016-12, Vol.4 (6), p.e00278-n/a

2016

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Inhibition of inflammatory gene expression in adipose tissue and development of glucose intolerance in DIO mice by a chemokine receptor 2/5 dual antagonist

The FASEB journal, 2009-04, Vol.23 (S1)

2009

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Application of the low-valent titanium reductive elimination of 1,6-dibenzoate-2,4-dienes to the total synthesis of 6(E)-5(S)-12(R)-leukotriene B4

Tetrahedron letters, 1993-03, Vol.34 (11), p.1807-1810

1993

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Chemoselective Arylsulfenylation of 2-Aminoimidazol[1,2-a]pyridines by Phenyliodine(III) Bis(trifluoroacetate) (PIFA)

Synthesis (Stuttgart), 1998-06, Vol.1998 (6), p.867-872

Hamdouchi, Chafiq

1998

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New one-step process for the synthesis of functionalized 1,6-dioxaspiro[4,5]decanes

Tetrahedron, 1995-07, Vol.51 (31), p.8507-8524

1995

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Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4333-4341

2003

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Asymmetric synthesis of the C-1-C-8 fragment of leukotriene B4 and C-11-C-20 fragments of leukotriene B4 and 12(S)-hydroxy-5,8,14(Z), 10(E) eicosatetraenoic acid

Tetrahedron: asymmetry, 1991, Vol.2 (6), p.457-469

1991

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Structural basis for GPR40 allosteric agonism and incretin stimulation

New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types

Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral Nociceptors

2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity

Novel route to the synthesis of 4-quinolyl isothiocyanates

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

The Role of GPR40 (FFAR1) in Pharmacological vs Physiological Control of Incretin Secretion

The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines

3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2- a]pyridine

Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

Abstract C129: Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors

A new approach to the asymmetric cyclopropanation via a chiral sulfinyl group

Cloning and functional characterization of the rabbit C-C chemokine receptor 2

Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes

Inhibition of inflammatory gene expression in adipose tissue and development of glucose intolerance in DIO mice by a chemokine receptor 2/5 dual antagonist

Application of the low-valent titanium reductive elimination of 1,6-dibenzoate-2,4-dienes to the total synthesis of 6(E)-5(S)-12(R)-leukotriene B4

Chemoselective Arylsulfenylation of 2-Aminoimidazol[1,2-a]pyridines by Phenyliodine(III) Bis(trifluoroacetate) (PIFA)

New one-step process for the synthesis of functionalized 1,6-dioxaspiro[4,5]decanes

Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation

Asymmetric synthesis of the C-1-C-8 fragment of leukotriene B4 and C-11-C-20 fragments of leukotriene B4 and 12(S)-hydroxy-5,8,14(Z), 10(E) eicosatetraenoic acid

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