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Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Journal of medicinal chemistry, 2005-07, Vol.48 (14), p.4628-4653

2005

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Small Molecule Inhibitors of Tumor-Promoted Angiogenesis, Including Protein Tyrosine Kinase Inhibitors

Pharmacology & therapeutics (Oxford), 1999-05, Vol.82 (2), p.169-193

1999

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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

The EMBO journal, 1998-10, Vol.17 (20), p.5896-5904

1998

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Antiangiogenic agents

Current Opinion in Biotechnology, 1999-12, Vol.10 (6), p.544-549

1999

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Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1752-1763

1998

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In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1433

1997

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In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase

The Journal of pharmacology and experimental therapeutics, 1998-07, Vol.286 (1), p.569

1998

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5457-5465

1998

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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (18), p.2415-2420

1997

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Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor

The Journal of pharmacology and experimental therapeutics, 1997-06, Vol.281 (3), p.1446

1997

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INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Life sciences (1973), 1998, Vol.62 (2), p.143-150

1998

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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2893-2905

1995

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Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3759-3771

1995

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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3276-3292

1998

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303

1997

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Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Bioorganic & medicinal chemistry letters, 1993-10, Vol.3 (10), p.2119-2124

1993

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Overview: Recent Advances in Angiotensin II Receptor Antagonists

Expert opinion on therapeutic patents, 1993-05, Vol.3 (5), p.581-596

1993

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Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues

Journal of medicinal chemistry, 1992-03, Vol.35 (6), p.1032-1042

1992

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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1915-1926

2001

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

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3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4200-4211

2000

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A comparison of nucleophilic reactions of 3-benzenesulfonyloxyalloxazine and its 1-methyl analog

Journal of heterocyclic chemistry, 1987-07, Vol.24 (4), p.1013-1024

1987

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Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs

Journal of medicinal chemistry, 1989-07, Vol.32 (7), p.1517-1522

1989

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Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.57-62

1994

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Inhibitors of Glycinamide Ribonucleotide Formyltransferase as Potential Cytotoxic Agents. Synthesis of 5-Deaza-5,6,7,8-tetrahydrohomofolic Acid, 5-Deaza-5,6,7,8-tetrahydroisohomofolic Acid, and 10-Formyl-5-deaza-5,6,7,8-tetrahydroisohomofolic Acid

Journal of organic chemistry, 1994-11, Vol.59 (23), p.7092-7095

1994

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Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Small Molecule Inhibitors of Tumor-Promoted Angiogenesis, Including Protein Tyrosine Kinase Inhibitors

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

Antiangiogenic agents

Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor

INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors

Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1' sites

Overview: Recent Advances in Angiotensin II Receptor Antagonists

Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues

Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and Related 2-Urea Derivatives Are Potent and Selective Inhibitors of the FGF Receptor-1 Tyrosine Kinase

A comparison of nucleophilic reactions of 3-benzenesulfonyloxyalloxazine and its 1-methyl analog

Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs

Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity

Inhibitors of Glycinamide Ribonucleotide Formyltransferase as Potential Cytotoxic Agents. Synthesis of 5-Deaza-5,6,7,8-tetrahydrohomofolic Acid, 5-Deaza-5,6,7,8-tetrahydroisohomofolic Acid, and 10-Formyl-5-deaza-5,6,7,8-tetrahydroisohomofolic Acid

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