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Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands

Developmental cell, 2017-01, Vol.40 (2), p.193-201

2017

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Protein O-fucosylation: structure and function

Current opinion in structural biology, 2019-06, Vol.56, p.78-86

2019

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Significance of glycosylation in Notch signaling

Biochemical and biophysical research communications, 2014-10, Vol.453 (2), p.235-242

2014

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Biological functions of fucose in mammals

Glycobiology (Oxford), 2017-07, Vol.27 (7), p.601-618

2017

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Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

Nature chemical biology, 2019-09, Vol.15 (9), p.853-864

2019

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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6331), p.1320-1324

2017

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Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2

The Journal of biological chemistry, 2020-10, Vol.295 (43), p.14710-14722

2020

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O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15964-15973

2017

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Regulation of Notch Function by O-Glycosylation

Advances in experimental medicine and biology, 2018-01, Vol.1066, p.59-78

2018

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Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome

PloS one, 2017-09, Vol.12 (9), p.e0184903-e0184903

2017

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Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

Current opinion in structural biology, 2011-10, Vol.21 (5), p.583-589

2011

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Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

Current biology, 2015-02, Vol.25 (3), p.286-295

2015

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Diseases related to Notch glycosylation

Molecular aspects of medicine, 2021-06, Vol.79, p.100938-100938, Article 100938

2021

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Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling

The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102616-102616, Article 102616

2022

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Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development

Glycobiology (Oxford), 2024-06, Vol.34 (8)

2024

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ROLE OF GLYCOSYLATION IN DEVELOPMENT

Annual review of biochemistry, 2004, Vol.73 (1), p.491-537

2004

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Novel roles for O-linked glycans in protein folding

Glycoconjugate journal, 2014-10, Vol.31 (6-7), p.417-426

2014

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Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (36), p.E8395-E8402

2018

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Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch

The Journal of biological chemistry, 2016-07, Vol.291 (31), p.16348-16360

2016

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Novel roles for O-linked glycans in protein folding

Glycoconjugate journal, 2014-10, Vol.31 (6-7), p.417-426

2014

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Negative regulation of notch signaling by xylose

PLoS genetics, 2013-06, Vol.9 (6), p.e1003547-e1003547

2013

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Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene

PLoS genetics, 2017-04, Vol.13 (4), p.e1006696-e1006696

2017

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Identification, function, and biological relevance of POGLUT2 and POGLUT3

Biochemical Society transactions, 2022-04, Vol.50 (2), p.1003-1012

2022

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Structure of the IFNγ receptor complex guides design of biased agonists

Nature (London), 2019-03, Vol.567 (7746), p.56-60

2019

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Analyzing the Effects of O-Fucosylation on Secretion of ADAMTS Proteins Using Cell-Based Assays

Methods in molecular biology (Clifton, N.J.), 2020-01, Vol.2043, p.25

2020

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Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands

Protein O-fucosylation: structure and function

Significance of glycosylation in Notch signaling

Biological functions of fucose in mammals

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

Regulation of Notch Function by O-Glycosylation

Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

Diseases related to Notch glycosylation

Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling

Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development

ROLE OF GLYCOSYLATION IN DEVELOPMENT

Novel roles for O-linked glycans in protein folding

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch

Novel roles for O-linked glycans in protein folding

Negative regulation of notch signaling by xylose

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene

Identification, function, and biological relevance of POGLUT2 and POGLUT3

Structure of the IFNγ receptor complex guides design of biased agonists

Analyzing the Effects of O-Fucosylation on Secretion of ADAMTS Proteins Using Cell-Based Assays

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