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A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

Drug metabolism and disposition, 2015-06, Vol.43 (6), p.908-915

2015

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Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Journal of pharmaceutical sciences, 2012-11, Vol.101 (11), p.4308-4326

2012

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Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

European journal of drug metabolism and pharmacokinetics, 2011-03, Vol.36 (1), p.1-16

2011

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1840-1849

2011

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Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

International journal of molecular sciences, 2017-07, Vol.18 (7), p.1553

2017

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An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes

Journal of pharmacological and toxicological methods, 2012-11, Vol.66 (3), p.270-275

2012

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The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

Drug metabolism letters, 2017-06, Vol.11 (2), p.111

2017

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On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Journal of pharmaceutical sciences, 2009-06, Vol.98 (6), p.1922-1927

2009

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Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1253-1261

2016

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High-Throughput, 384-Well, LC-MS/MS CYP Inhibition Assay Using Automation, Cassette-Analysis Technique and Streamlined Data Analysis

Drug metabolism letters, 2011-08, Vol.5 (3), p.220-230

2011

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Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Nature microbiology, 2022-10, Vol.7 (10), p.1536-1546

2022

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Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.430-440

2017

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Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2104-2113

2013

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Consistency of the Novel Equations for Determination of Hepatic Clearance and Drug Time Course in Liver that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water

Journal of pharmaceutical sciences, 2012-02, Vol.101 (2), p.516-518

2012

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1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9

Drug metabolism and disposition, 2014-05, Vol.42 (5), p.813-817

2014

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On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay

Journal of pharmacokinetics and pharmacodynamics, 2013-12, Vol.40 (6), p.683-689

2013

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Comparative pharmacokinetic and disposition studies of [1-14C]1-eicosanylcyclohexane, a surrogate mineral hydrocarbon, in female Fischer-344 and Sprague-Dawley rats

Drug metabolism and disposition, 2002-12, Vol.30 (12), p.1470-1477

2002

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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human

Xenobiotica, 2011-12, Vol.41 (12), p.1088-1099

2011

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Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluorination

Chemical research in toxicology, 2010-05, Vol.23 (5), p.861-863

2010

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Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition

Chemical research in toxicology, 2011-10, Vol.24 (10), p.1668-1677

2011

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Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

Drug metabolism letters, 2012-05, Vol.6 (1), p.43-53

2012

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For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

Toxicology research (Cambridge), 2014-01, Vol.3 (3), p.184-190

2014

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Metabolic Stability Screen for Drug Discovery Using Cassette Analysis and Column Switching

Drug metabolism letters, 2007-01, Vol.1 (1), p.67-72

2007

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Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats

Drug metabolism and disposition, 1999-12, Vol.27 (12), p.1456

1999

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High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis

Drug metabolism letters, 2011-08, Vol.5 (3), p.220

2011

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A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes

The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

High-Throughput, 384-Well, LC-MS/MS CYP Inhibition Assay Using Automation, Cassette-Analysis Technique and Streamlined Data Analysis

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Consistency of the Novel Equations for Determination of Hepatic Clearance and Drug Time Course in Liver that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water

1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9

On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay

Comparative pharmacokinetic and disposition studies of [1-14C]1-eicosanylcyclohexane, a surrogate mineral hydrocarbon, in female Fischer-344 and Sprague-Dawley rats

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human

Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluorination

Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition

Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

Metabolic Stability Screen for Drug Discovery Using Cassette Analysis and Column Switching

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats

High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis

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