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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

The Journal of immunology (1950), 2016-09, Vol.197 (6), p.2421-2433

2016

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Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

Immunity (Cambridge, Mass.), 2011-08, Vol.35 (2), p.194-207

2011

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An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

Kidney international, 2016-09, Vol.90 (3), p.525-539

2016

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Journal of leukocyte biology, 2010-12, Vol.88 (6), p.1171-1180

2010

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Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Frontiers in medicine, 2022-07, Vol.9, p.931293-931293

2022

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Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5952-5956

2011

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Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood

The Journal of biological chemistry, 2007-11, Vol.282 (46), p.33295-33304

2007

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Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4 + T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

The Journal of immunology (1950), 2020-08, Vol.205 (4), p.957-967

2020

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The c-Jun NH2-Terminal Kinase Is Essential for Epidermal Growth Factor Expression during Epidermal Morphogenesis

Proceedings of the National Academy of Sciences - PNAS, 2004-09, Vol.101 (39), p.14114-14119

2004

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Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

Journal of inflammation (London, England), 2012-03, Vol.9 (1), p.11-11, Article 11

2012

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Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3485-3488

2009

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Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells

Journal of immunological methods, 2019-04, Vol.467, p.19-28

2019

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Corrigendum to “Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells” [Journal of Immunological Methods 467 (2019) 19-28]

Journal of immunological methods, 2019-05, Vol.468, p.67-67

2019

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Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling

The Journal of biological chemistry, 2003-11, Vol.278 (47), p.47089-47097

2003

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

Rheumatology (Oxford, England), 2009-11, Vol.48 (11), p.1352-1358

2009

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TRIL is involved in cytokine production in the brain following Escherichia coli infection

The Journal of immunology (1950), 2014-08, Vol.193 (4), p.1911-1919

2014

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c-Jun N-Terminal Kinase (JNK) Repression during the Inflammatory Response? Just Say NO

Proceedings of the National Academy of Sciences - PNAS, 2000-12, Vol.97 (26), p.14022-14024

2000

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Discovery of indazoles as inhibitors of Tpl2 kinase

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4758-4761

2011

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Inhibitors of Tumor Progression Loci-2 (Tpl2) Kinase and Tumor Necrosis Factor α (TNF-α) Production: Selectivity and in Vivo Antiinflammatory Activity of Novel 8-Substituted-4-anilino-6-aminoquinoline-3-carbonitriles

Journal of medicinal chemistry, 2007-09, Vol.50 (19), p.4728-4745

2007

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JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure

Genes & development, 2003-05, Vol.17 (10), p.1271-1280

2003

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Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line

Journal of cellular biochemistry, 2002, Vol.86 (1), p.1-11

2002

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Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

Bioorganic & medicinal chemistry, 2007-10, Vol.15 (19), p.6425-6442

2007

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Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5288-5292

2005

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A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production

Journal of pharmacological and toxicological methods, 2007-07, Vol.56 (1), p.67-71

2007

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Analysis of c-Jun n-terminal kinase regulation and function

Methods in Enzymology, 2002, Vol.345, p.413-425

2002

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors

Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4 + T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

The c-Jun NH2-Terminal Kinase Is Essential for Epidermal Growth Factor Expression during Epidermal Morphogenesis

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells

Corrigendum to “Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells” [Journal of Immunological Methods 467 (2019) 19-28]

Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

TRIL is involved in cytokine production in the brain following Escherichia coli infection

c-Jun N-Terminal Kinase (JNK) Repression during the Inflammatory Response? Just Say NO

Discovery of indazoles as inhibitors of Tpl2 kinase

Inhibitors of Tumor Progression Loci-2 (Tpl2) Kinase and Tumor Necrosis Factor α (TNF-α) Production: Selectivity and in Vivo Antiinflammatory Activity of Novel 8-Substituted-4-anilino-6-aminoquinoline-3-carbonitriles

JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure

Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships

A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production

Analysis of c-Jun n-terminal kinase regulation and function

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