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Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Journal of lipid research, 2014-08, Vol.55 (8), p.1553-1595

2014

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Bile salts of vertebrates: structural variation and possible evolutionary significance[S]

Journal of lipid research, 2010-02, Vol.51 (2), p.226-246

2010

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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

Hepatology (Baltimore, Md.), 2016-01, Vol.63 (1), p.185-196

2016

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MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

Cell metabolism, 2015-02, Vol.21 (2), p.298-311

2015

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A “Forward Genomics” Approach Links Genotype to Phenotype using Independent Phenotypic Losses among Related Species

Cell reports (Cambridge), 2012-10, Vol.2 (4), p.817-823

2012

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Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

Molecular and cellular endocrinology, 2011-03, Vol.334 (1), p.39-48

2011

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Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway

Physiological and biochemical zoology, 2010-03, Vol.83 (2), p.308-321

2010

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The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice

PloS one, 2013-03, Vol.8 (3), p.e60270-e60270

2013

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Human cecal bile acids: concentration and spectrum

American journal of physiology: Gastrointestinal and liver physiology, 2007-07, Vol.293 (1), p.G256-G263

2007

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Evolution of pharmacologic specificity in the pregnane X receptor

BMC evolutionary biology, 2008-04, Vol.8 (1), p.103, Article 103

2008

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Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine

American journal of physiology: Gastrointestinal and liver physiology, 2012-05, Vol.302 (9), p.G925-G936

2012

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Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury

Hepatology (Baltimore, Md.), 2015-10, Vol.62 (4), p.1227-1236

2015

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Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites

BMC evolutionary biology, 2010-05, Vol.10 (1), p.133

2010

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Functional evolution of the vitamin D and pregnane X receptors

BMC evolutionary biology, 2007-11, Vol.7 (1), p.222, Article 222

2007

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Evolution of the bile salt nuclear receptor FXR in vertebrates

Journal of lipid research, 2008-07, Vol.49 (7), p.1577-1587

2008

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The changing metabolic landscape of bile acids - keys to metabolism and immune regulation

Nature reviews. Gastroenterology & hepatology, 2024-07, Vol.21 (7), p.493-516

2024

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How bile acids and the microbiota interact to shape host immunity

Nature reviews. Immunology, 2024-07

2024

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Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis

Hepatology (Baltimore, Md.), 2016-12, Vol.64 (6), p.2151-2164

2016

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In memoriam: the maestro of bile acids: Alan F. Hofmann (1931–2021)

Journal of lipid research, 2021, Vol.62, p.100137, Article 100137

2021

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Evolution of the Pregnane X Receptor: Adaptation to Cross-Species Differences in Biliary Bile Salts

Molecular endocrinology (Baltimore, Md.), 2005-07, Vol.19 (7), p.1720-1739

2005

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Novel biotransformation and physiological properties of norursodeoxycholic acid in humans

Hepatology (Baltimore, Md.), 2005-12, Vol.42 (6), p.1391-1398

2005

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Improved Chemical Synthesis, X-Ray Crystallographic Analysis, and NMR Characterization of (22R)-/(22S)-Hydroxy Epimers of Bile Acids

Lipids, 2014-11, Vol.49 (11), p.1169-1180

2014

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Altered lipid metabolism in gastroschisis: A novel hypothesis

American journal of medical genetics. Part A, 2013-08, Vol.161A (8), p.1860-1865

2013

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Ligand specificity and evolution of liver X receptors

The Journal of steroid biochemistry and molecular biology, 2008-05, Vol.110 (1), p.83-94

2008

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The underappreciated diversity of bile acid modifications

Cell, 2024-03, Vol.187 (7), p.1801-1818.e20

2024

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Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Bile salts of vertebrates: structural variation and possible evolutionary significance[S]

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

A “Forward Genomics” Approach Links Genotype to Phenotype using Independent Phenotypic Losses among Related Species

Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway

The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice

Human cecal bile acids: concentration and spectrum

Evolution of pharmacologic specificity in the pregnane X receptor

Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine

Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury

Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites

Functional evolution of the vitamin D and pregnane X receptors

Evolution of the bile salt nuclear receptor FXR in vertebrates

The changing metabolic landscape of bile acids - keys to metabolism and immune regulation

How bile acids and the microbiota interact to shape host immunity

Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis

In memoriam: the maestro of bile acids: Alan F. Hofmann (1931–2021)

Evolution of the Pregnane X Receptor: Adaptation to Cross-Species Differences in Biliary Bile Salts

Novel biotransformation and physiological properties of norursodeoxycholic acid in humans

Improved Chemical Synthesis, X-Ray Crystallographic Analysis, and NMR Characterization of (22R)-/(22S)-Hydroxy Epimers of Bile Acids

Altered lipid metabolism in gastroschisis: A novel hypothesis

Ligand specificity and evolution of liver X receptors

The underappreciated diversity of bile acid modifications

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