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Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance

Frontiers in oncology, 2018-05, Vol.8, p.173-173

2018

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Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

PLoS computational biology, 2023-01, Vol.19 (1), p.e1010833-e1010833

2023

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Targeting glutamine transport to suppress melanoma cell growth

International journal of cancer, 2014-09, Vol.135 (5), p.1060-1071

2014

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Quantitative analysis of tumour spheroid structure

eLife, 2021-11, Vol.10

2021

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Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

British journal of cancer, 2023-05, Vol.128 (10), p.1807-1818

2023

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RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes

International journal of cancer, 2019-06, Vol.144 (12), p.3070-3085

2019

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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (8), p.3041-3046

2008

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Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

Molecular cancer therapeutics, 2006-05, Vol.5 (5), p.1136-1144

2006

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Persister state-directed transitioning and vulnerability in melanoma

Nature communications, 2022-06, Vol.13 (1), p.3055-3055, Article 3055

2022

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Real-time cell cycle imaging during melanoma growth, invasion, and drug response

Pigment cell and melanoma research, 2014-09, Vol.27 (5), p.764-776

2014

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Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737

Clinical cancer research, 2012-02, Vol.18 (3), p.783-795

2012

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The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

Clinical cancer research, 2008-01, Vol.14 (1), p.230-239

2008

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Fluorescence-Based Quantitative and Spatial Analysis of Tumour Spheroids: A Proposed Tool to Predict Patient-Specific Therapy Response

Frontiers in digital health, 2021-05, Vol.3, p.668390-668390

2021

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Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS

Acta neuropathologica, 2015-11, Vol.130 (5), p.661-678

2015

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Modeling Melanoma In Vitro and In Vivo

Healthcare (Basel), 2013-12, Vol.2 (1), p.27-46

2013

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PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

Pigment cell and melanoma research, 2010-12, Vol.23 (6), p.820-827

2010

Volltextzugriff (PDF)

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

EMBO molecular medicine, 2017-08, Vol.9 (8), p.1011-1029

2017

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Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay

PloS one, 2011-06, Vol.6 (6), p.e20623

2011

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Designing and interpreting 4D tumour spheroid experiments

Communications biology, 2022-01, Vol.5 (1), p.91-91, Article 91

2022

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Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

Clinical cancer research, 2018-06, Vol.24 (12), p.2901-2912

2018

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An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

Cancer research (Chicago, Ill.), 2007, Vol.67 (1), p.209-217

2007

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Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression

Cancers, 2021-07, Vol.13 (15), p.3733

2021

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The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis

Frontiers in medicine, 2018-11, Vol.5, p.307-307

2018

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Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

Molecular oncology, 2019-07, Vol.13 (7), p.1503-1518

2019

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NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

EBioMedicine, 2017-02, Vol.16 (C), p.63-75

2017

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Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance

Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

Targeting glutamine transport to suppress melanoma cell growth

Quantitative analysis of tumour spheroid structure

Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes

Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

Persister state-directed transitioning and vulnerability in melanoma

Real-time cell cycle imaging during melanoma growth, invasion, and drug response

Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

Fluorescence-Based Quantitative and Spatial Analysis of Tumour Spheroids: A Proposed Tool to Predict Patient-Specific Therapy Response

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS

Modeling Melanoma In Vitro and In Vivo

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay

Designing and interpreting 4D tumour spheroid experiments

Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

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