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Oral Tecovirimat for the Treatment of Smallpox

The New England journal of medicine, 2018-07, Vol.379 (1), p.44-53

2018

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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

PloS one, 2011-08, Vol.6 (8), p.e23237

2011

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ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Journal of antimicrobial chemotherapy, 2015-05, Vol.70 (5), p.1367-1380

2015

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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

PLoS pathogens, 2024-02, Vol.20 (2), p.e1012007-e1012007

2024

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Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

Expert review of anti-infective therapy, 2023-03, Vol.21 (3), p.235-242

2023

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A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.15-25

2013

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Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6246-6253

2013

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Antimicrobial Agents and Chemotherapy, 2013-04, Vol.57 (4), p.1902-1912

2013

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Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus

Journal of Virology, 2011-09, Vol.85 (17), p.9176-9187

2011

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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Journal of Virology, 2008-11, Vol.82 (21), p.10768-10775

2008

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Development of ST-246® for Treatment of Poxvirus Infections

Viruses, 2010-11, Vol.2 (11), p.2409-2435

2010

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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.4118-4124

2007

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ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Antimicrobial Agents and Chemotherapy, 2009-05, Vol.53 (5), p.1817-1822

2009

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Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

Antimicrobial Agents and Chemotherapy, 2007-02, Vol.51 (2), p.689-695

2007

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In Vitro Efficacy of ST246 against Smallpox and Monkeypox

Antimicrobial Agents and Chemotherapy, 2009-03, Vol.53 (3), p.1007-1012

2009

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An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Expert review of anti-infective therapy, 2021-03, Vol.19 (3), p.331-344

2021

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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4900-4905

2012

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Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

Antiviral research, 2011-04, Vol.90 (1), p.70-79

2011

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ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.4999-5009

2009

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Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (2), p.838-843

2010

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The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus

Journal of Virology, 2007-07, Vol.81 (13), p.7310-7315

2007

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Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

Antimicrobial Agents and Chemotherapy, 2008-05, Vol.52 (5), p.1721-1727

2008

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Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection

PloS one, 2013-04, Vol.8 (4), p.e61514

2013

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Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Antimicrobial Agents and Chemotherapy, 2013-03, Vol.57 (3), p.1136-1143

2013

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Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge

Journal of Virology, 2008-04, Vol.82 (7), p.3517-3529

2008

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Oral Tecovirimat for the Treatment of Smallpox

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential

A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein

Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Development of ST-246® for Treatment of Poxvirus Infections

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

In Vitro Efficacy of ST246 against Smallpox and Monkeypox

An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications

Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

The Vaccinia Virus F13L YPPL Motif Is Required for Efficient Release of Extracellular Enveloped Virus

Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection

Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge

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