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The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science?

The Journal of Toxicological Sciences, 2016/12/31, Vol.41(Special), pp.SP49-SP67

Horii, Ikuo

2016

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Current status and future perspective of computational toxicology in drug safety assessment under ontological intellection

The Journal of Toxicological Sciences, 2019, Vol.44(11), pp.721-735

2019

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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

The Journal of Toxicological Sciences, 2021, Vol.46(3), pp.99-114

2021

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Toxic effect onset and evaluations of medicinal drugs - horizon for Darwinian toxicological thought

The Journal of Toxicological Sciences, 2010/08/01, Vol.35(4), pp.425-435

Horii, Ikuo

2010

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AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

Hepatology (Baltimore, Md.), 2012-06, Vol.55 (6), p.1889-1900

2012

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CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE − REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION

The Journal of Toxicological Sciences, 2007, Vol.32(4), pp.401-409

2007

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

Cell, 1996-05, Vol.85 (5), p.707-720

1996

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INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES -"WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?"

The Journal of Toxicological Sciences, 2005, Vol.30(1), pp.61-72

2005

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Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta

The Journal of Toxicological Sciences, 2013/02/01, Vol.38(1), pp.159-167

2013

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MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion

The Journal of Toxicological Sciences, 2011/10/01, Vol.36(5), pp.601-611

2011

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IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM

The Journal of Toxicological Sciences, 2006, Vol.31(1), pp.23-34

2006

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PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL

The Journal of Toxicological Sciences, 2006, Vol.31(4), pp.315-324

2006

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ADVANTAGES OF IN VITRO CYTOTOXICITY TESTING BY USING PRIMARY RAT HEPATOCYTES IN COMPARISON WITH ESTABLISHED CELL LINES

The Journal of Toxicological Sciences, 2002, Vol.27(3), pp.229-237

2002

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6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta

The Journal of Toxicological Sciences, 2012/06/01, Vol.37(3), pp.607-615

2012

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INTEGRATED NMR-BASED METABONOMIC INVESTIGATION OF EARLY METABOLIC EFFECTS OF ETHYLENE GLYCOL MONOMETHYL ETHER (EGME) ON MALE REPRODUCTIVE ORGANS IN RATS

The Journal of Toxicological Sciences, 2007, Vol.32(5), pp.515-528

2007

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INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER: TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS

The Journal of Toxicological Sciences, 2006, Vol.31(1), pp.49-60

2006

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IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH

The Journal of Toxicological Sciences, 2005, Vol.30(3), pp.213-227

2005

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Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen

Toxicologic pathology, 2008-06, Vol.36 (4), p.581-591

2008

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The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

Bioorganic & medicinal chemistry, 2000-07, Vol.8 (7), p.1697-1706

2000

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S3A-36-2 Regulatory science for the safety evaluation to risk assessment/management in non-clinical drug research and development

Journal of Pharmacological Sciences, 2012, Vol.118 (suppl), p.52-52

Ikuo Horii

2012

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Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats

Toxicological sciences, 2005-05, Vol.85 (1), p.675-682

2005

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In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes

Journal of applied toxicology, 2008-03, Vol.28 (2), p.227-236

2008

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EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS

The Journal of Toxicological Sciences, 2005, Vol.30(3), pp.229-237

2005

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EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES

The Journal of Toxicological Sciences, 2005, Vol.30(3), pp.195-206

2005

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In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells

Journal of applied toxicology, 2008-03, Vol.28 (2), p.237-248

2008

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The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science?

Current status and future perspective of computational toxicology in drug safety assessment under ontological intellection

Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

Toxic effect onset and evaluations of medicinal drugs - horizon for Darwinian toxicological thought

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function

CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE − REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES -"WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?"

Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta

MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion

IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM

PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL

ADVANTAGES OF IN VITRO CYTOTOXICITY TESTING BY USING PRIMARY RAT HEPATOCYTES IN COMPARISON WITH ESTABLISHED CELL LINES

6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta

INTEGRATED NMR-BASED METABONOMIC INVESTIGATION OF EARLY METABOLIC EFFECTS OF ETHYLENE GLYCOL MONOMETHYL ETHER (EGME) ON MALE REPRODUCTIVE ORGANS IN RATS

INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER: TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS

IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH

Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

S3A-36-2 Regulatory science for the safety evaluation to risk assessment/management in non-clinical drug research and development

Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats

In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes

EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS

EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES

In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells

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