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Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium

PLoS computational biology, 2020-09, Vol.16 (9), p.e1008086-e1008086

2020

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Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study

PLoS computational biology, 2021-03, Vol.17 (3), p.e1008177-e1008177

2021

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Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

PLoS computational biology, 2016-12, Vol.12 (12), p.e1005245-e1005245

2016

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An Update on the Structure of hERG

Frontiers in pharmacology, 2020-01, Vol.10, p.1572-1572

2020

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In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition

Scientific reports, 2024-02, Vol.14 (1), p.3185-3185, Article 3185

2024

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The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

Pharmacology & therapeutics (Oxford), 2013-08, Vol.139 (2), p.213-248

2013

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Journal of biomolecular screening, 2016-01, Vol.21 (1), p.1-11

2016

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The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Pharmacology & therapeutics (Oxford), 2008-08, Vol.119 (2), p.118-132

2008

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

The Journal of biological chemistry, 2018-05, Vol.293 (18), p.7040-7057

2018

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Emerging therapeutic targets in the short QT syndrome

Expert opinion on therapeutic targets, 2018-05, Vol.22 (5), p.439-451

2018

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Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome

International journal of molecular sciences, 2022-05, Vol.23 (10), p.5735

2022

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Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

Frontiers in physiology, 2020-11, Vol.11, p.547577-547577

2020

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Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

PLoS computational biology, 2017-06, Vol.13 (6), p.e1005593-e1005593

2017

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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Journal of molecular and cellular cardiology, 2015-09, Vol.86, p.42-53

2015

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Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

Frontiers in physiology, 2023-04, Vol.14, p.1163339-1163339

2023

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Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling - Insights From Computational Modelling

Frontiers in physiology, 2022-04, Vol.13, p.877428-877428

2022

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Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

ACS chemical biology, 2017-03, Vol.12 (3), p.825-832

2017

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Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

Frontiers in physiology, 2020-12, Vol.11, p.546508-546508

2020

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Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency

Annals of noninvasive electrocardiology, 2023-11, Vol.28 (6), p.e13077-n/a

2023

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Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

Journal of molecular and cellular cardiology, 2014-09, Vol.74 (100), p.220-230

2014

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Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome

PLoS computational biology, 2011-12, Vol.7 (12), p.e1002313-e1002313

2011

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Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

Pharmaceuticals (Basel, Switzerland), 2023-08, Vol.16 (9), p.1204

2023

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Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

Frontiers in pharmacology, 2022-01, Vol.12, p.794620-794620

2022

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Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study

PLoS computational biology, 2018-11, Vol.14 (11), p.e1006594-e1006594

2018

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In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Scientific reports, 2017-08, Vol.7 (1), p.8469-14, Article 8469

2017

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Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium

Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

An Update on the Structure of hERG

In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition

The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

Emerging therapeutic targets in the short QT syndrome

Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling - Insights From Computational Modelling

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

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