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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4659-4670

2023

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The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Scientific reports, 2022-03, Vol.12 (1), p.3589-3589, Article 3589

2022

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Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case

Drug discovery today, 2013-10, Vol.18 (19-20), p.1014-1024

2013

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sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension

Hypertension research, 2021-12, Vol.44 (12), p.1568-1577

2021

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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC

Respiratory research, 2022-10, Vol.23 (1), p.1-272, Article 272

2022

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New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions

European journal of applied physiology, 2018-01, Vol.118 (1), p.195-203

2018

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Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease

Journal of pharmacological and toxicological methods, 2018-03, Vol.90, p.7-12

2018

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High-Throughput Screening in Drug Discovery

1. Aufl., 2006

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Imaging the Permeability Pore Transition in Single Mitochondria

Biophysical journal, 1998-04, Vol.74 (4), p.2129-2137

1998

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Local calcium gradients during excitation–contraction coupling and alternans in atrial myocytes

The Journal of physiology, 2003-01, Vol.546 (1), p.19-31

2003

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Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Cardiovascular research, 2021-06, Vol.117 (7), p.1616-1631

2021

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Functional coupling between glycolysis and excitation—contraction coupling underlies alternans in cat heart cells

The Journal of physiology, 2000-05, Vol.524 (3), p.795-806

2000

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Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage

American journal of nephrology, 2021-10, Vol.52 (8), p.642-652

2021

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Functional cell-based assays in microliter volumes for ultra-high throughput screening

Combinatorial chemistry & high throughput screening, 2008-08, Vol.11 (7), p.495

2008

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A New Therapeutic Framework for Atrial Fibrillation Drug Development

Circulation research, 2020-06, Vol.127 (1), p.184-201

2020

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A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3′,5′-cyclic monophosphate pathway

Analytical biochemistry, 2007-04, Vol.363 (2), p.219-227

2007

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A novel approach for quantification of the future unmet medical need in right ventricular dysfunction

Drug discovery today, 2022-05, Vol.27 (5), p.1326-1331

2022

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Sarcoplasmic Reticulum Ca2+Release Flux Underlying Ca2+Sparks in Cardiac Muscle

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (8), p.4176-4181

1997

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Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure

European journal of heart failure, 2021-05, Vol.23 (5), p.743-750

2021

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“Digital biomarkers” in preclinical heart failure models — a further step towards improved translational research

Heart failure reviews, 2023-01, Vol.28 (1), p.249-260

2023

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4659-4670

2023

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High-throughput-screening in drug discovery, volume 35

2006

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Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients?

Journal of bioenergetics and biomembranes, 2000-02, Vol.32 (1), p.27-33

2000

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Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist

Journal of cardiovascular pharmacology, 2019-07, Vol.74 (1), p.44

2019

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Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

Biochemical journal, 1999-10, Vol.343 Pt 2 (2), p.311-317

1999

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist

The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Big pharma screening collections: more of the same or unique libraries? The AstraZeneca–Bayer Pharma AG case

sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension

Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC

New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions

Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease

High-Throughput Screening in Drug Discovery

Imaging the Permeability Pore Transition in Single Mitochondria

Local calcium gradients during excitation–contraction coupling and alternans in atrial myocytes

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

Functional coupling between glycolysis and excitation—contraction coupling underlies alternans in cat heart cells

Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage

Functional cell-based assays in microliter volumes for ultra-high throughput screening

A New Therapeutic Framework for Atrial Fibrillation Drug Development

A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3′,5′-cyclic monophosphate pathway

A novel approach for quantification of the future unmet medical need in right ventricular dysfunction

Sarcoplasmic Reticulum Ca2+Release Flux Underlying Ca2+Sparks in Cardiac Muscle

Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure

“Digital biomarkers” in preclinical heart failure models — a further step towards improved translational research

BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist

High-throughput-screening in drug discovery, volume 35

Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients?

Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist

Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

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