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GDC-0449—A potent inhibitor of the hedgehog pathway

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5576-5581

2009

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Callipeltoside A: Total Synthesis, Assignment of the Absolute and Relative Configuration, and Evaluation of Synthetic Analogues

Journal of the American Chemical Society, 2002-09, Vol.124 (35), p.10396-10415

2002

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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2408-2411

2010

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Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6413-6433

2013

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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (12), p.4921-4937

2013

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Liposomal packaging generates Wnt protein with in vivo biological activity

PloS one, 2008-08, Vol.3 (8), p.e2930-e2930

2008

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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Molecular cancer therapeutics, 2017-05, Vol.16 (5), p.871-878

2017

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Total Synthesis of Deschlorocallipeltoside A

Journal of the American Chemical Society, 2001-09, Vol.123 (38), p.9449-9450

2001

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Total synthesis of brevetoxin A

Nature (London), 1998-03, Vol.392 (6673), p.264-269

1998

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Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis

Angewandte Chemie (International ed.), 2002-03, Vol.41 (5), p.841-843

2002

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

The Journal of biological chemistry, 2013-09, Vol.288 (37), p.26926-26943

2013

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An unusual regioselectivity in the Pd-catalyzed cross coupling of alkynes. A correction

Tetrahedron letters, 2001-06, Vol.42 (23), p.3775-3778

2001

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Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion

Chemistry : a European journal, 1999-02, Vol.5 (2), p.646-658

1999

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Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Journal of medicinal chemistry, 2011-11, Vol.54 (22), p.7815-7833

2011

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Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

Chemistry : a European journal, 1999-02, Vol.5 (2), p.599-617

1999

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The Wittig and Related Reactions in Natural Product Synthesis

Liebigs Annalen, 1997-07, Vol.1997 (7), p.1283-1301

1997

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Total Synthesis of Brevetoxin A: Part 2: Second Generation Strategy and Construction of EFGH Model System

Chemistry : a European journal, 1999-02, Vol.5 (2), p.618-627

1999

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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.989-1000

2018

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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Science translational medicine, 2012-12, Vol.4 (164), p.164ra161

2012

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Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9490-9507

2017

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Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5536-5545

2012

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Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.770-792

2014

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GDC-0449—A potent inhibitor of the hedgehog pathway

Callipeltoside A: Total Synthesis, Assignment of the Absolute and Relative Configuration, and Evaluation of Synthetic Analogues

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Liposomal packaging generates Wnt protein with in vivo biological activity

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Total Synthesis of Deschlorocallipeltoside A

Total synthesis of brevetoxin A

Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

An unusual regioselectivity in the Pd-catalyzed cross coupling of alkynes. A correction

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

The Wittig and Related Reactions in Natural Product Synthesis

Total Synthesis of Brevetoxin A: Part 2: Second Generation Strategy and Construction of EFGH Model System

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

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