UB Paderborn / Katalog / Suche / in CDI

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2746-2754

2014

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Impact of Excited-State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes

Journal of the American Chemical Society, 2020-06, Vol.142 (25), p.10942-10954

2020

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Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles

Proceedings of the National Academy of Sciences - PNAS, 2024-01, Vol.121 (2), p.e2311700120

2024

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Metabolism of Strained Rings: Glutathione S -transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation

Drug metabolism and disposition, 2019-11, Vol.47 (11), p.1247-1256

2019

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Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

Journal of medicinal chemistry, 2016-07, Vol.59 (14), p.6658-6670

2016

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Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone

Journal of labelled compounds & radiopharmaceuticals, 2024-04, Vol.67 (4), p.145-153

2024

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A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules

Bioorganic & medicinal chemistry, 2015-09, Vol.23 (17), p.5603-5609

2015

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Characterization and demonstration of drug compound ring-chain tautomer formation and its impacts on quality control

Journal of pharmaceutical and biomedical analysis, 2021-05, Vol.198, p.114020-114020, Article 114020

2021

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Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts

ACS chemical biology, 2017-01, Vol.12 (1), p.132-141

2017

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CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity

Drug metabolism and disposition, 2016-09, Vol.44 (9), p.1480-1489

2016

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Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

Chemical research in toxicology, 2008-10, Vol.21 (10), p.2035-2041

2008

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Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1341-1348

2016

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4,4,16‐Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation

ChemMedChem, 2020-12, Vol.15 (23), p.2317-2331

2020

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Electrochemical Generation of Electrophilic Drug Metabolites: Characterization of Amodiaquine Quinoneimine and Cysteinyl Conjugates by MS, IR, and NMR

Chemical research in toxicology, 2008-04, Vol.21 (4), p.928-935

2008

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Synthesis of 2 C‐14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole

Journal of labelled compounds & radiopharmaceuticals, 2017-05, Vol.60 (6), p.294-301

2017

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Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.571

2009

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Synthesis of 1λ 6 ,2,4,6‐Thiatriazine‐1,3,5‐Trione Derivatives

European journal of organic chemistry, 2019-08, Vol.2019 (29), p.4731-4740

2019

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Synthesis of 1λ6,2,4,6‐Thiatriazine‐1,3,5‐Trione Derivatives

European journal of organic chemistry, 2019-08, Vol.2019 (29), p.4731-4740

2019

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Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP)

Journal of labelled compounds & radiopharmaceuticals, 2016-07, Vol.59 (9), p.340-345

2016

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Synthesis of 1β‐hydroxydeoxycholic acid in H‐2 and unlabeled forms

Journal of labelled compounds & radiopharmaceuticals, 2017-04, Vol.60 (4), p.221-229

2017

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Structural analysis of five new monosialylated oligosaccharides from human milk

Archives of biochemistry and biophysics, 1992-08, Vol.296 (2), p.597-610

1992

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Isolation and structural analysis of three new disialylated oligosaccharides from human milk

Archives of biochemistry and biophysics, 1990-05, Vol.278 (2), p.297-311

1990

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Synthesis of 1[beta]-hydroxydeoxycholic acid in H-2 and unlabeled forms

Journal of labelled compounds & radiopharmaceuticals, 2017-04, Vol.60 (4), p.221

2017

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Structural analysis of the N-linked oligosaccharides from murine glycophorin

Archives of biochemistry and biophysics, 1991-11, Vol.291 (1), p.76-88

1991

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Nuclear magnetic resonance and conformational investigations of the pentasaccharide of the Forssman antigen and overlapping di-, tri-, and tetra-saccharide sequences

Carbohydrate research, 1994-04, Vol.257 (1), p.35-54

1994

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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Impact of Excited-State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes

Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles

Metabolism of Strained Rings: Glutathione S -transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone

A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules

Characterization and demonstration of drug compound ring-chain tautomer formation and its impacts on quality control

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity

Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane

4,4,16‐Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation

Electrochemical Generation of Electrophilic Drug Metabolites: Characterization of Amodiaquine Quinoneimine and Cysteinyl Conjugates by MS, IR, and NMR

Synthesis of 2 C‐14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole

Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR

Synthesis of 1λ 6 ,2,4,6‐Thiatriazine‐1,3,5‐Trione Derivatives

Synthesis of 1λ6,2,4,6‐Thiatriazine‐1,3,5‐Trione Derivatives

Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP)

Synthesis of 1β‐hydroxydeoxycholic acid in H‐2 and unlabeled forms

Structural analysis of five new monosialylated oligosaccharides from human milk

Isolation and structural analysis of three new disialylated oligosaccharides from human milk

Synthesis of 1[beta]-hydroxydeoxycholic acid in H-2 and unlabeled forms

Structural analysis of the N-linked oligosaccharides from murine glycophorin

Nuclear magnetic resonance and conformational investigations of the pentasaccharide of the Forssman antigen and overlapping di-, tri-, and tetra-saccharide sequences

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