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Calcium Dyshomeostasis Drives Pathophysiology and Neuronal Demise in Age-Related Neurodegenerative Diseases

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13243

Griffioen, Gerard

2023

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PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability

Molecular microbiology, 2005-02, Vol.55 (3), p.862-880

2005

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Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease

Molecular neurodegeneration, 2018-09, Vol.13 (1), p.50-50, Article 50

2018

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Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

Mutation research, 2009-05, Vol.676 (1), p.113-130

2009

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D04 Blood glucose and insulin levels following an oral glucose challenge are promising biomarkers in the zQ175 knock-in mouse model of huntington’s disease

Journal of neurology, neurosurgery and psychiatry, 2021-09, Vol.92 (Suppl 1), p.A15-A15

2021

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Cytosolic calcium: judge, jury and executioner of neurodegeneration in Alzheimer’s disease and beyond: towards a unified hypothesis

Alzheimer's & dementia, 2023-05, Vol.19 (8), p.3701-3717

2023

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Evaluation of Distance Metrics and Spatial Autocorrelation in Uniform Manifold Approximation and Projection Applied to Mass Spectrometry Imaging Data

Analytical chemistry (Washington), 2019-05, Vol.91 (9), p.5706-5714

2019

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Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Alzheimer's & dementia, 2023-08, Vol.19 (8), p.3701-3717

2023

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Feedback Inhibition on Cell Wall Integrity Signaling by Zds1 Involves Gsk3 Phosphorylation of a cAMP-dependent Protein Kinase Regulatory Subunit

The Journal of biological chemistry, 2003-06, Vol.278 (26), p.23460-23471

2003

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Nucleocytoplasmic Distribution of Budding Yeast Protein Kinase A Regulatory Subunit Bcy1 Requires Zds1 and Is Regulated by Yak1-Dependent Phosphorylation of Its Targeting Domain

Molecular and Cellular Biology, 2001-01, Vol.21 (2), p.511-523

2001

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Nutritional Control of Nucleocytoplasmic Localization of cAMP-dependent Protein Kinase Catalytic and Regulatory Subunits in Saccharomyces cerevisiae

The Journal of biological chemistry, 2000-01, Vol.275 (2), p.1449-1456

2000

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Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

International journal of alzheimer's disease, 2010, Vol.2010 (2010), p.1-9

2010

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Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

Science (American Association for the Advancement of Science), 2024-05, Vol.384 (6699), p.eadd6260

2024

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Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease

European journal of pharmaceutical sciences, 2011-08, Vol.43 (5), p.386-392

2011

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Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease

BioMed research international, 2014-01, Vol.2014 (2014), p.1-14

2014

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Modifying Rap1-signalling by targeting Pde6[delta] is neuroprotective in models of Alzheimer's disease

Molecular neurodegeneration, 2018-09, Vol.13 (1)

2018

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Characterization of α‐synuclein aggregation and synergistic toxicity with protein tau in yeast

The FEBS journal, 2005-03, Vol.272 (6), p.1386-1400

2005

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A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential

Biochimica et biophysica acta, 2006-03, Vol.1762 (3), p.312-318

2006

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Targeting disease, not disease targets: Innovative approaches in tackling neurodegenerative disorders

IDrugs : the investigational drugs journal, 2007-04, Vol.10 (4), p.259

Griffioen, Gerard

2007

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Transcription activation of yeast ribosomal protein genes requires additional elements apart from binding sites for Abf1p or Rap1p

Nucleic acids research, 1995-05, Vol.23 (9), p.1475-1480

1995

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Molecular mechanisms controlling the localisation of protein kinase A

Current genetics, 2002-07, Vol.41 (4), p.199-207

2002

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Characterization of [alpha]-synuclein aggregation and synergistic toxicity with protein tau in yeast

The FEBS journal, 2005-03, Vol.272 (6), p.1386

2005

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Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources

Microbiology (Society for General Microbiology), 1996-07, Vol.142 ( Pt 7) (7), p.1775-1782

1996

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Signalling pathways leading to transcriptional regulation of genes involved in the activation of glycolysis in yeast

Molecular microbiology, 1997-08, Vol.25 (3), p.483-493

1997

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Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes

Microbiology (Society for General Microbiology), 1996-08, Vol.142 ( Pt 8) (8), p.2279-2287

1996

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Calcium Dyshomeostasis Drives Pathophysiology and Neuronal Demise in Age-Related Neurodegenerative Diseases

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease

Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

D04 Blood glucose and insulin levels following an oral glucose challenge are promising biomarkers in the zQ175 knock-in mouse model of huntington’s disease

Cytosolic calcium: judge, jury and executioner of neurodegeneration in Alzheimer’s disease and beyond: towards a unified hypothesis

Evaluation of Distance Metrics and Spatial Autocorrelation in Uniform Manifold Approximation and Projection Applied to Mass Spectrometry Imaging Data

Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Feedback Inhibition on Cell Wall Integrity Signaling by Zds1 Involves Gsk3 Phosphorylation of a cAMP-dependent Protein Kinase Regulatory Subunit

Nucleocytoplasmic Distribution of Budding Yeast Protein Kinase A Regulatory Subunit Bcy1 Requires Zds1 and Is Regulated by Yak1-Dependent Phosphorylation of Its Targeting Domain

Nutritional Control of Nucleocytoplasmic Localization of cAMP-dependent Protein Kinase Catalytic and Regulatory Subunits in Saccharomyces cerevisiae

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease

Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease

Modifying Rap1-signalling by targeting Pde6[delta] is neuroprotective in models of Alzheimer's disease

Characterization of α‐synuclein aggregation and synergistic toxicity with protein tau in yeast

A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential

Targeting disease, not disease targets: Innovative approaches in tackling neurodegenerative disorders

Transcription activation of yeast ribosomal protein genes requires additional elements apart from binding sites for Abf1p or Rap1p

Molecular mechanisms controlling the localisation of protein kinase A

Characterization of [alpha]-synuclein aggregation and synergistic toxicity with protein tau in yeast

Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources

Signalling pathways leading to transcriptional regulation of genes involved in the activation of glycolysis in yeast

Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes

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