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Activated protein C: biased for translation

Blood, 2015-05, Vol.125 (19), p.2898-2907

2015

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Activated protein C, protease activated receptor 1, and neuroprotection

Blood, 2018-07, Vol.132 (2), p.159-169

2018

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The cytoprotective protein C pathway

Blood, 2007-04, Vol.109 (8), p.3161-3172

2007

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Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Blood, 2017-12, Vol.130 (24), p.2664-2677

2017

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Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Blood, 2012-12, Vol.120 (26), p.5237-5246

2012

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Cytoprotective protein C pathways and implications for stroke and neurological disorders

Trends in neurosciences (Regular ed.), 2011-04, Vol.34 (4), p.198-209

2011

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Endothelial and Antithrombotic Actions of HDL

Circulation research, 2006-06, Vol.98 (11), p.1352-1364

2006

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Blood—spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.3912-3912

2014

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PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

Blood, 2018-03, Vol.131 (11), p.1163-1171

2018

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3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

Nature medicine, 2016-09, Vol.22 (9), p.1050-1055

2016

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Protein C anticoagulant and cytoprotective pathways

International journal of hematology, 2012-04, Vol.95 (4), p.333-345

2012

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Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

The Journal of biological chemistry, 2017-05, Vol.292 (21), p.8616-8629

2017

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Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

PloS one, 2021-05, Vol.16 (5), p.e0252142-e0252142

2021

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Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

Nature communications, 2022-08, Vol.13 (1), p.5062-5062, Article 5062

2022

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COVID‐19 hypothesis: Activated protein C for therapy of virus‐induced pathologic thromboinflammation

Research and practice in thrombosis and haemostasis, 2020-05, Vol.4 (4), p.506-509

2020

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Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model

International journal of molecular sciences, 2024-01, Vol.25 (2), p.1255

2024

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Molecular interaction site on procoagulant myosin for factor Xa–dependent prothrombin activation

The Journal of biological chemistry, 2019-10, Vol.294 (41), p.15176-15181

2019

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Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

Current pharmaceutical design, 2012-09, Vol.18 (27), p.4215-4222

2012

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3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina

International journal of molecular sciences, 2023-06, Vol.24 (13), p.10642

2023

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Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism

Journal of Atherosclerosis and Thrombosis, 2016/10/01, Vol.23(10), pp.1159-1167

2016

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Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

Frontiers in neuroscience, 2020-04, Vol.14, p.333-333

2020

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3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation

International journal of molecular sciences, 2022-11, Vol.23 (22), p.14196

2022

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Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Blood, 2016-10, Vol.128 (14), p.1870-1878

2016

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Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Current pharmaceutical design, 2013, Vol.19 (42), p.7479-7485

2013

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3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

Frontiers in neuroscience, 2022-03, Vol.16, p.841916-841916

2022

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Activated protein C: biased for translation

Activated protein C, protease activated receptor 1, and neuroprotection

The cytoprotective protein C pathway

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Cytoprotective protein C pathways and implications for stroke and neurological disorders

Endothelial and Antithrombotic Actions of HDL

Blood—spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

Protein C anticoagulant and cytoprotective pathways

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

COVID‐19 hypothesis: Activated protein C for therapy of virus‐induced pathologic thromboinflammation

Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model

Molecular interaction site on procoagulant myosin for factor Xa–dependent prothrombin activation

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina

Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism

Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

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