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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.101972-101972, Article 101972

2022

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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.247-265

2019

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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Journal of medicinal chemistry, 2024-04

2024

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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6779-6800

2018

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Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations

The Journal of biological chemistry, 2012-04, Vol.287 (17), p.13598-13610

2012

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Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates

The Journal of biological chemistry, 2004-04, Vol.279 (17), p.18034-18045

2004

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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1586-1593

2021

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Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase

Biochemistry (Easton), 2001-11, Vol.40 (45), p.13538-13547

2001

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In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance

Science advances, 2024-07, Vol.10 (30), p.eadl4013

2024

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Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Nature structural & molecular biology, 2001-05, Vol.8 (5), p.402-406

2001

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Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor

Biochemistry (Easton), 2004-02, Vol.43 (5), p.1171-1183

2004

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Structural Insights into the Avian AICAR Transformylase Mechanism

Biochemistry (Easton), 2002-12, Vol.41 (52), p.15505-15513

2002

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Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR

Biochemistry (Easton), 2002-12, Vol.41 (48), p.14206-14215

2002

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Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor β-DADF Identifies the Folate Binding Site

Biochemistry (Easton), 2003-09, Vol.42 (37), p.10904-10914

2003

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The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

Nature structural & molecular biology, 1995-09, Vol.2 (9), p.797-806

1995

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New Insights into Inhibitor Design from the Crystal Structure and NMR Studies of Escherichia coli GAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid

Biochemistry (Easton), 1999-12, Vol.38 (51), p.16783-16793

1999

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Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.330-330

2021

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A pH-dependent stabilization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 Å

Journal of molecular biology, 1998-08, Vol.281 (3), p.485-499

1998

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Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Journal of medicinal chemistry, 2018-04, Vol.62 (1)

2018

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Insights into Mechanism of Glucokinase Activation

The Journal of biological chemistry, 2012-04, Vol.287 (17), p.13598-13610

2012

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Insights into Mechanism of Glucokinase Activation: observation of multiple distinct protein conformations

The Journal of biological chemistry, 2012-02, Vol.287 (17)

2012

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Corrigendum to “Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation” [Bioorg. Med. Chem. 18 (2010) 3307]

Bioorganic & medicinal chemistry, 2010-10, Vol.18 (19), p.7144-7144

2010

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Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli

Acta crystallographica. Section D, Biological crystallography., 2000-08, Vol.56 (8), p.1051-1054

2000

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Characterization of Specific N -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1175-1184

2020

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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations

Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Unexpected Formation of an Epoxide-Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase

In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor

Structural Insights into the Avian AICAR Transformylase Mechanism

Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR

Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor β-DADF Identifies the Folate Binding Site

The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

New Insights into Inhibitor Design from the Crystal Structure and NMR Studies of Escherichia coli GAR Transformylase in Complex with β-GAR and 10-Formyl-5,8,10-trideazafolic Acid

Abstract 330: Engineering electrophile-sensitive kinase mutants to accelerate oncology target validation

A pH-dependent stabilization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 Å

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Insights into Mechanism of Glucokinase Activation

Insights into Mechanism of Glucokinase Activation: observation of multiple distinct protein conformations

Corrigendum to “Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation” [Bioorg. Med. Chem. 18 (2010) 3307]

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Characterization of Specific N -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

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