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Insulin, insulin receptors, and cancer

Journal of endocrinological investigation, 2016-12, Vol.39 (12), p.1365-1376

2016

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Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

Molecular and Cellular Biology, 1999-05, Vol.19 (5), p.3278-3288

1999

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A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

Diabetes (New York, N.Y.), 1999-09, Vol.48 (9), p.1881-1884

1999

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XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity

Diabetes, obesity & metabolism, 2013-03, Vol.15 (3), p.272-275

2013

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Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

Diabetes (New York, N.Y.), 2000-01, Vol.49 (1), p.13-19

2000

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Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling

Clinical cancer research, 1999-07, Vol.5 (7), p.1935-1944

1999

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Insulin receptor activation by IGF-II in breast cancers : evidence for a new autocrine/paracrine mechanism

Oncogene, 1999-04, Vol.18 (15), p.2471-2479

1999

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Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia

International Journal of Obesity, 2004-03, Vol.28 (3), p.363-369

2004

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Transcriptional regulation of human insulin receptor gene by the high‐mobility group protein HMGI(Y)

The FASEB journal, 2001-02, Vol.15 (2), p.492-500

2001

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Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling

Diabetes (New York, N.Y.), 1998-07, Vol.47 (7), p.1095-1100

1998

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Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

Nature (London), 1995-02, Vol.373 (6513), p.448-451

1995

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Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-α gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity

Diabetologia, 1997-03, Vol.40 (3), p.282-289

1997

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Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients

Diabetes care, 1990-01, Vol.13 (1), p.1-8

1990

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Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor

The Journal of biological chemistry, 1990-04, Vol.265 (11), p.5960-5963

1990

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PC-1 content in skeletal muscle of non-obese, non-diabetic subjects : relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity

Diabetologia, 1996-10, Vol.39 (10), p.1190-1195

1996

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Mechanism of glucocorticoid receptor down-regulation by glucocorticoids

The Journal of biological chemistry, 1988-02, Vol.263 (6), p.2581-2584

1988

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Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer

Cancer research (Chicago, Ill.), 1993-08, Vol.53 (16), p.3736-3740

1993

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Cholecystokinin bioactivity in human plasma: molecular forms, responses to feeding, and relationship to gallbladder contraction

The Journal of clinical investigation, 1985-04, Vol.75 (4), p.1144-1152

1985

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The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract

Nature biotechnology, 1997-12, Vol.15 (13), p.1378-1382

1997

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The insulin receptor: molecular biology and transmembrane signaling

Endocrine reviews, 1987-08, Vol.8 (3), p.235-255

GOLDFINE, I. D

1987

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The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

Cell, 1985-04, Vol.40 (4), p.747-758

1985

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Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes

Diabetes technology & therapeutics, 2000, Vol.2 (3), p.401-413

2000

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Insulin receptor expression and function in human breast cancer cell lines

Cancer research (Chicago, Ill.), 1992-07, Vol.52 (14), p.3924-3930

1992

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Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein

The Journal of biological chemistry, 1994-04, Vol.269 (17), p.12503-12507

1994

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Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol

Gastroenterology (New York, N.Y. 1943), 1984-09, Vol.87 (3), p.542-549

1984

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Insulin, insulin receptors, and cancer

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

Insulin and Insulin-like Growth Factor-I (IGF-I) Receptor Overexpression in Breast Cancers Leads to Insulin/IGF-I Hybrid Receptor Overexpression: Evidence for a Second Mechanism of IGF-I Signaling

Insulin receptor activation by IGF-II in breast cancers : evidence for a new autocrine/paracrine mechanism

Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia

Transcriptional regulation of human insulin receptor gene by the high‐mobility group protein HMGI(Y)

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-α gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity

Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients

Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor

PC-1 content in skeletal muscle of non-obese, non-diabetic subjects : relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity

Mechanism of glucocorticoid receptor down-regulation by glucocorticoids

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer

Cholecystokinin bioactivity in human plasma: molecular forms, responses to feeding, and relationship to gallbladder contraction

The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract

The insulin receptor: molecular biology and transmembrane signaling

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes

Insulin receptor expression and function in human breast cancer cell lines

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein

Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol

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