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Mechanism-Based Target Identification and Drug Discovery in Cancer Research

Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5460), p.1969-1973

Gibbs, Jackson B.

2000

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The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

Annual review of pharmacology and toxicology, 1997-01, Vol.37 (1), p.143-166

1997

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Lung cancer cell lines harboring MET gene amplification are dependent on met for growth and survival

Cancer research (Chicago, Ill.), 2007-03, Vol.67 (5), p.2081-2088

2007

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nature medicine, 1995-08, Vol.1 (8), p.792-797

1995

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MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor

Cancer research (Chicago, Ill.), 2010-02, Vol.70 (4), p.1524-1533

2010

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Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

American journal of medical genetics. Part A, 2010-01, Vol.152A (1), p.4-24

2010

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Cell, 1994-04, Vol.77 (2), p.175-178

1994

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Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3356-3368

1999

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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

Molecular and Cellular Biology, 1997-08, Vol.17 (8), p.4454-4464

1997

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Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

Cancer research (Chicago, Ill.), 1998-03, Vol.58 (6), p.1253-1259

1998

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The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.2027-2030

2002

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Molecular and Cellular Biology, 1998-01, Vol.18 (1), p.85-92

1998

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Pathways of Ras Function: Connections to the Actin Cytoskeleton

Advances in Cancer Research, 1993-01, Vol.62, p.19-64

1993

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Chemistry and Biology of Cylindrols: Novel Inhibitors of Ras Farnesyl-Protein Transferase from Cylindrocarpon lucidum

Journal of organic chemistry, 1996-11, Vol.61 (22), p.7727-7737

1996

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Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1146-1150

2006

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Steady-state kinetic mechanism of ras farnesyl:protein transferase

Biochemistry (Easton), 1992-04, Vol.31 (15), p.3800-3807

1992

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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3301-3306

1999

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PDGF induction of tyrosine phosphorylation of GTPase activating protein

Nature (London), 1989-12, Vol.342 (6250), p.711-714

1989

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Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase

Journal of natural products (Washington, D.C.), 1993-11, Vol.56 (11), p.1923-1929

1993

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Cloning of bovine GAP and its interaction with oncogenic ras p21

Nature (London), 1988-09, Vol.335 (6185), p.90-93

1988

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Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Biochemistry (Easton), 1993-05, Vol.32 (19), p.5167-5176

1993

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Mechanism-Based Target Identification and Drug Discovery in Cancer Research

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

Lung cancer cell lines harboring MET gene amplification are dependent on met for growth and survival

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor

N-Arylpiperazinone Inhibitors of Farnesyltransferase: Discovery and Biological Activity

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

Potent N-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Pathways of Ras Function: Connections to the Actin Cytoskeleton

Chemistry and Biology of Cylindrols: Novel Inhibitors of Ras Farnesyl-Protein Transferase from Cylindrocarpon lucidum

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase

Steady-state kinetic mechanism of ras farnesyl:protein transferase

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

PDGF induction of tyrosine phosphorylation of GTPase activating protein

Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Cloning of bovine GAP and its interaction with oncogenic ras p21

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

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