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Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

Biochimica et biophysica acta, 2014-08, Vol.1842 (8), p.1282-1294

2014

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Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology

Molecular neurodegeneration, 2021-01, Vol.16 (1), p.5-5, Article 5

2021

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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease

Science translational medicine, 2016-12, Vol.8 (368), p.368ra174

2016

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Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (47), p.18754-18759

2007

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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Neurobiology of disease, 2016-09, Vol.93, p.96-114

2016

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Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease

PloS one, 2012-06, Vol.7 (6), p.e38113

2012

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Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease

Journal of neuroinflammation, 2012-10, Vol.9 (1), p.241-241, Article 241

2012

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Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

Neurobiology of disease, 2015-01, Vol.73, p.70-82

2015

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Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease

Frontiers in pharmacology, 2021-04, Vol.12, p.631375

2021

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The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons

The Journal of biological chemistry, 2013-07, Vol.288 (30), p.21955-21971

2013

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Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase

The Journal of biological chemistry, 2013-07, Vol.288 (29), p.20843-20855

2013

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α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity

The Journal of neuroscience, 2011-02, Vol.31 (6), p.2035-2051

2011

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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes

Neurotoxicology (Park Forest South), 2018-01, Vol.64, p.204-218

2018

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Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking

Neuroscience, 2022-04, Vol.487, p.166-183

2022

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Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease

The Journal of biological chemistry, 2014-12, Vol.289 (50), p.34743-34767

2014

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The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease

The Journal of biological chemistry, 2013-07, Vol.288 (30), p.21955-21971

2013

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Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1

Biochimica et biophysica acta. General subjects, 2017-11, Vol.1861 (11), p.2640-2651

2017

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Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

Free radical biology & medicine, 2010-12, Vol.49 (11), p.1674-1684

2010

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Munc13 Is a Molecular Target of Bryostatin 1

Biochemistry (Easton), 2019-07, Vol.58 (27), p.3016-3030

2019

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Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

Journal of neuroimmune pharmacology, 2016-06, Vol.11 (2), p.259-278

2016

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Novel Bryostatin‐1 Targets: Mammalian Unc13‐1 and Unc13‐2 Isoforms

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse

Neuroscience letters, 2013-08, Vol.549, p.57-62

2013

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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Neurobiology of disease, 2016-09, Vol.93, p.96-114

2016

Volltextzugriff (PDF)

Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death

The Journal of biological chemistry, 2014-12, Vol.289 (50), p.34743-34767

2014

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Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease

Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease

The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons

Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase

α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes

Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking

Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease

The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease

Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

FRI-151 RNA editing for the treatment of Alpha-1 antitrypsin deficiency

Munc13 Is a Molecular Target of Bryostatin 1

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

Novel Bryostatin‐1 Targets: Mammalian Unc13‐1 and Unc13‐2 Isoforms

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death

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