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Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Nature communications, 2022-04, Vol.13 (1), p.1783-1783, Article 1783

2022

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Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Pharmacological reviews, 2023-09, Vol.75 (5), p.885

2023

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The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Journal of experimental & clinical cancer research, 2018-09, Vol.37 (1), p.234-15, Article 234

2018

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Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

Cell discovery, 2021-03, Vol.7 (1), p.16-16, Article 16

2021

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β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice

British journal of pharmacology, 2018-01, Vol.175 (2), p.320-334

2018

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Identification of potent and selective small molecule inhibitors of the cation channel TRPM4

British journal of pharmacology, 2018-06, Vol.175 (12), p.2504-2519

2018

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Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?

British journal of pharmacology, 2017-06, Vol.174 (11), p.1464-1483

Gertsch, Jürg

2017

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Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom

Scientific reports, 2017-01, Vol.7 (1), p.41177-41177, Article 41177

2017

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β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

Free radical biology & medicine, 2012-04, Vol.52 (8), p.1325-1333

2012

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Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

Proceedings of the National Academy of Sciences - PNAS, 2017-06, Vol.114 (25), p.E5006-E5015

2017

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Variation of the Detergent-Binding Capacity and Phospholipid Content of Membrane Proteins When Purified in Different Detergents

Biophysical journal, 2014-04, Vol.106 (8), p.1660-1670

2014

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LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease

Metabolism, clinical and experimental, 2024-04, Vol.153, p.155793-155793, Article 155793

2024

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Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma

Cancers, 2021-04, Vol.13 (8), p.1934

2021

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Synthesis of Morpholine‐Based Analogues of (−)‐Zampanolide and Their Biological Activity

Chemistry : a European journal, 2021-04, Vol.27 (19), p.5936-5943

2021

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Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures

Planta medica, 2011-07, Vol.77 (11), p.1086

Gertsch, Jürg

2011

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Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors

European journal of medicinal chemistry, 2024-01, Vol.263, p.115916-115916, Article 115916

2024

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CNS Drug Discovery in Academia: Where Basic Research Meets Innovation

Chembiochem : a European journal of chemical biology, 2024-07, p.e202400397

2024

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Structure, Function and Pharmacology of SLC7 Family Members and Homologues

Chimia, 2022-12, Vol.76 (12), p.1011

2022

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Pharmacokinetics and pharmacodynamics of γ‐hydroxybutyrate in healthy subjects

British journal of clinical pharmacology, 2016-05, Vol.81 (5), p.980-988

2016

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The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health

Planta medica, 2016-07, Vol.82 (11-12), p.920

Gertsch, Jürg

2016

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The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis

European journal of medicinal chemistry, 2020-12, Vol.208, p.112858, Article 112858

2020

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Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo

Oncotarget, 2017-04, Vol.8 (15), p.24604-24620

2017

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Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

European journal of medicinal chemistry, 2018-06, Vol.154, p.155-171

2018

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How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems

Journal of ethnopharmacology, 2009-03, Vol.122 (2), p.177-183

Gertsch, Jürg

2009

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The Evaluation of l‐Tryptophan Derivatives as Inhibitors of the l‐Type Amino Acid Transporter LAT1 (SLC7A5)

ChemMedChem, 2022-09, Vol.17 (17), p.e202200308-n/a

2022

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Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4

Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?

Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom

β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

Variation of the Detergent-Binding Capacity and Phospholipid Content of Membrane Proteins When Purified in Different Detergents

LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease

Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma

Synthesis of Morpholine‐Based Analogues of (−)‐Zampanolide and Their Biological Activity

Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures

Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors

CNS Drug Discovery in Academia: Where Basic Research Meets Innovation

Structure, Function and Pharmacology of SLC7 Family Members and Homologues

Pharmacokinetics and pharmacodynamics of γ‐hydroxybutyrate in healthy subjects

The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health

The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis

Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems

The Evaluation of l‐Tryptophan Derivatives as Inhibitors of the l‐Type Amino Acid Transporter LAT1 (SLC7A5)

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