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Obtaining structural and functional information for GPCRs using the substituted-cysteine accessibility method (SCAM)

Current pharmaceutical biotechnology, 2014-01, Vol.15 (10), p.980-986

Liapakis, George

2014

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Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)

Molecules (Basel, Switzerland), 2024-08, Vol.29 (15), p.3647

2024

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Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells

Molecules (Basel, Switzerland), 2024-08, Vol.29 (17), p.4127

2024

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The G-protein coupled receptor family: actors with many faces

Current pharmaceutical design, 2012-01, Vol.18 (2), p.175-185

2012

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Rational Design, Synthesis and Binding Affinity Studies of Anthraquinone Derivatives Conjugated to Gonadotropin-Releasing Hormone (GnRH) Analogues towards Selective Immunosuppression of Hormone-Dependent Cancer

International journal of molecular sciences, 2023-10, Vol.24 (20), p.15232

2023

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The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site

Arabian journal of chemistry, 2019-12, Vol.12 (8), p.5062-5078

2019

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Structural and Functional Insights into CRF Peptides and Their Receptors

Biology (Basel, Switzerland), 2024-02, Vol.13 (2), p.120

2024

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Family B G Protein-coupled Receptors and their Ligands: From Structure to Function

Current medicinal chemistry, 2017-01, Vol.24 (31), p.3323

2017

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Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

Biomedicines, 2021-09, Vol.9 (9), p.1185

2021

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Role of Central and Peripheral CRH in Skin

Current molecular pharmacology, 2018-01, Vol.11 (1), p.72

2018

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Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

The Journal of biological chemistry, 2001-08, Vol.276 (31), p.29171-29177

2001

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Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes and the differentiation of mouse 3T3L1 pre-adipocytes

PloS one, 2014-05, Vol.9 (5), p.e97060-e97060

2014

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Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor

Current medicinal chemistry, 2016-01, Vol.23 (1), p.36-59

2016

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Understanding Corticotropin Releasing Factor Receptor (CRFR) Activation Using Structural Models

Current molecular pharmacology, 2017, Vol.10 (4)

2017

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The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives

European journal of medicinal chemistry, 2012-09, Vol.55, p.358-374

2012

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The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response

Current molecular pharmacology, 2018-01, Vol.11 (1), p.39

2018

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Editorial: Corticotropin Releasing Factor (CRF) and Its Receptors: From Structure to Function in Health and Disease (Part II)

Current molecular pharmacology, 2018-02, Vol.11 (1)

Liapakis, George

2018

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Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

Molecular pharmacology, 2009-04, Vol.75 (4), p.793-800

2009

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Editorial: Corticotropin Releasing Factor (CRF) and its Receptors: From Structure to Function in Health and Disease (Part I)

Current molecular pharmacology, 2017-10, Vol.10 (4)

Liapakis, George

2017

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A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts

PloS one, 2011-07, Vol.6 (7), p.e21654-e21654

2011

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G protein-coupled receptor signaling to Kir channels in Xenopus oocytes

Current pharmaceutical biotechnology, 2014-01, Vol.15 (10), p.987-995

2014

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Constitutive Activation of the β2 Adrenergic Receptor Alters the Orientation of Its Sixth Membrane-spanning Segment

The Journal of biological chemistry, 1997-07, Vol.272 (30), p.18546-18549

1997

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Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2015-02, Vol.11 (1), p.50-59

2015

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Rational drug design paradigms: the odyssey for designing better drugs

Combinatorial chemistry & high throughput screening, 2015-01, Vol.18 (3), p.238-256

2015

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Design, Synthesis, and Biological Evaluations of Novel Thiazolo4,5-dpyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)

Molecules (Basel, Switzerland), 2024-08, Vol.29 (15)

2024

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Obtaining structural and functional information for GPCRs using the substituted-cysteine accessibility method (SCAM)

Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)

Cytotoxic Activity of Novel GnRH Analogs Conjugated with Mitoxantrone in Ovarian Cancer Cells

The G-protein coupled receptor family: actors with many faces

Rational Design, Synthesis and Binding Affinity Studies of Anthraquinone Derivatives Conjugated to Gonadotropin-Releasing Hormone (GnRH) Analogues towards Selective Immunosuppression of Hormone-Dependent Cancer

The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site

Structural and Functional Insights into CRF Peptides and Their Receptors

Family B G Protein-coupled Receptors and their Ligands: From Structure to Function

Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

Role of Central and Peripheral CRH in Skin

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes and the differentiation of mouse 3T3L1 pre-adipocytes

Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor

Understanding Corticotropin Releasing Factor Receptor (CRFR) Activation Using Structural Models

The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: A concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives

The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response

Editorial: Corticotropin Releasing Factor (CRF) and Its Receptors: From Structure to Function in Health and Disease (Part II)

Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

Editorial: Corticotropin Releasing Factor (CRF) and its Receptors: From Structure to Function in Health and Disease (Part I)

A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts

G protein-coupled receptor signaling to Kir channels in Xenopus oocytes

Constitutive Activation of the β2 Adrenergic Receptor Alters the Orientation of Its Sixth Membrane-spanning Segment

Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators

Rational drug design paradigms: the odyssey for designing better drugs

Design, Synthesis, and Biological Evaluations of Novel Thiazolo4,5-dpyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH)

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