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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Journal of organic chemistry, 2017-04, Vol.82 (7), p.3506-3512

2017

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Molecular metabolism (Germany), 2022-12, Vol.66, p.101638-101638, Article 101638

2022

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Chemical Synthesis of Insulin Analogs through a Novel Precursor

ACS chemical biology, 2014-03, Vol.9 (3), p.683-691

2014

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Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

Journal of peptide science, 2017-06, Vol.23 (6), p.455-465

2017

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A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

ACS chemical biology, 2011-02, Vol.6 (2), p.135-145

2011

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4697-4708

2021

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High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Organic letters, 2018-06, Vol.20 (12), p.3695-3699

2018

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Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

Peptides (New York, N.Y. : 1980), 2019-10, Vol.120, p.170116-170116, Article 170116

2019

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Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.6134-6143

2020

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A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

ACS chemical biology, 2019-08, Vol.14 (8), p.1829-1835

2019

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Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

ChemMedChem, 2018-04, Vol.13 (8), p.852-859

2018

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Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

Peptides (New York, N.Y. : 1980), 2018-02, Vol.100, p.18-23

2018

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Peptide lipidation stabilizes structure to enhance biological function

Molecular metabolism (Germany), 2013-11, Vol.2 (4), p.468-479

2013

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Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

RSC chemical biology, 2024-07, Vol.5 (8), p.763-775

2024

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Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases

Journal of peptide science, 2018-01, Vol.24 (1), p.n/a

2018

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Optimization of the native glucagon sequence for medicinal purposes

Journal of diabetes science and technology, 2010-11, Vol.4 (6), p.1322-1331

2010

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Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity

Journal of peptide science, 2015-03, Vol.21 (3), p.223-230

2015

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Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B‑Chain and Nonpeptide Linker

ACS chemical biology, 2013-08, Vol.8 (8), p.1822-1829

2013

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Functional association of the N-terminal residues with the central region in glucagon-related peptides

Journal of peptide science, 2011-10, Vol.17 (10), p.659-666

2011

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Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action

Journal of peptide science, 2011-03, Vol.17 (3), p.218-225

2011

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Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2

Blood, 2001-10, Vol.98 (8), p.2508-2517

2001

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New virus‐specific T‐helper epitopes of foot‐and‐mouth disease viral VP1 protein

FEBS letters, 1993-10, Vol.333 (1-2), p.175-178

1993

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New virus-specific T-helper epitopes of foot-and-mouth disease viral VP 1 protein

FEBS letters, 1993-10, Vol.333 (1), p.175-178

1993

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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

Science translational medicine, 2013-10, Vol.5 (209), p.209ra151

2013

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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Chemical Synthesis of Insulin Analogs through a Novel Precursor

Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

Peptide lipidation stabilizes structure to enhance biological function

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases

Optimization of the native glucagon sequence for medicinal purposes

Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity

Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B‑Chain and Nonpeptide Linker

Functional association of the N-terminal residues with the central region in glucagon-related peptides

Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action

Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2

New virus‐specific T‐helper epitopes of foot‐and‐mouth disease viral VP1 protein

New virus-specific T-helper epitopes of foot-and-mouth disease viral VP 1 protein

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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