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A single-cell atlas of chromatin accessibility in the human genome

Cell, 2021-11, Vol.184 (24), p.5985-6001.e19

2021

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Detection of human adaptation during the past 2000 years

Science (American Association for the Advancement of Science), 2016-11, Vol.354 (6313), p.760-764

2016

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The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

PloS one, 2013-01, Vol.8 (1), p.e55272-e55272

2013

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The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease

PLoS genetics, 2015-04, Vol.11 (4), p.e1005165-e1005165

2015

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Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

Nature genetics, 2021-04, Vol.53 (4), p.455-466

2021

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Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal

PLoS biology, 2023-08, Vol.21 (8), p.e3002233-e3002233

2023

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Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

PLoS genetics, 2015-12, Vol.11 (12), p.e1005694-e1005694

2015

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Common DNA sequence variation influences 3-dimensional conformation of the human genome

Genome Biology, 2019-11, Vol.20 (1), p.255-255, Article 255

2019

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Characterizing cis-regulatory elements using single-cell epigenomics

Nature reviews. Genetics, 2023-01, Vol.24 (1), p.21

2023

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A map of open chromatin in human pancreatic islets

Nature genetics, 2010-03, Vol.42 (3), p.255-259

2010

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Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Nature communications, 2019-05, Vol.10 (1), p.2078-2078, Article 2078

2019

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Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

PLoS genetics, 2021-05, Vol.17 (5), p.e1009531-e1009531

2021

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Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Nature communications, 2021-11, Vol.12 (1), p.6636-6636, Article 6636

2021

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Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus

PLoS genetics, 2014-09, Vol.10 (9), p.e1004633-e1004633

2014

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Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

PLoS genetics, 2023-06, Vol.19 (6), p.e1010759-e1010759

2023

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Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding

PLoS genetics, 2015-04, Vol.11 (4), p.e1005061-e1005061

2015

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Nutrient regulation of the islet epigenome controls adaptive insulin secretion

The Journal of clinical investigation, 2023-04, Vol.133 (8), p.1-15

2023

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Interpreting non-coding disease-associated human variants using single-cell epigenomics

Nature reviews. Genetics, 2023-08, Vol.24 (8), p.516

2023

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Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Genome medicine, 2019-03, Vol.11 (1), p.19-19, Article 19

2019

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Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

American journal of human genetics, 2015-12, Vol.97 (6), p.801-815

2015

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138-OR: Characterization and Prediction of Genetic Risk of T1D in Individuals without HLA-DR3 or HLA-DR4

Diabetes (New York, N.Y.), 2023-06, Vol.72 (Supplement_1), p.1

2023

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Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

eLife, 2021-02, Vol.10

2021

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A single-cell atlas of chromatin accessibility in the human genome

Detection of human adaptation during the past 2000 years

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease

Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Common DNA sequence variation influences 3-dimensional conformation of the human genome

Characterizing cis-regulatory elements using single-cell epigenomics

A map of open chromatin in human pancreatic islets

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus

Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Interpreting non-coding disease-associated human variants using single-cell epigenomics

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

138-OR: Characterization and Prediction of Genetic Risk of T1D in Individuals without HLA-DR3 or HLA-DR4

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

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