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Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Diabetes (New York, N.Y.), 2022-12, Vol.71 (12), p.2513-2529

2022

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Endoplasmic reticulum tubules limit the size of misfolded protein condensates

eLife, 2021-09, Vol.10

2021

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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

Nature communications, 2020-04, Vol.11 (1), p.2082-15, Article 2082

2020

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Nutrient regulation of the islet epigenome controls adaptive insulin secretion

The Journal of clinical investigation, 2023-04, Vol.133 (8), p.1-15

2023

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Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation

Trends in endocrinology and metabolism, 2021-07, Vol.32 (7), p.474-487

2021

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Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Cell death & disease, 2023-07, Vol.14 (7), p.399-399, Article 399

2023

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Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Cell reports (Cambridge), 2018-12, Vol.25 (10), p.2904-2918.e8

2018

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Global identification of MLL2-targeted loci reveals MLL2’s role in diverse signaling pathways

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (43), p.17603-17608

2012

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Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection

PLoS genetics, 2012-06, Vol.8 (6), p.e1002789-e1002789

2012

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OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas

Cancer research (Chicago, Ill.), 2010, Vol.70 (1), p.181-191

2010

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Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Molecular metabolism (Germany), 2022-01, Vol.55, p.101403-101403, Article 101403

2022

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Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells

PloS one, 2012-04, Vol.7 (4), p.e36211-e36211

2012

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Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma

PloS one, 2014-09, Vol.9 (9), p.e107156

2014

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High T Gives β Cells a Boost

Cell metabolism, 2016-05, Vol.23 (5), p.761-763

2016

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Mechanisms of β-cell functional adaptation to changes in workload

Diabetes, obesity & metabolism, 2016-09, Vol.18 (S1), p.78-86

2016

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Sizing up beta cells made from stem cells

Nature biotechnology, 2022-07, Vol.40 (7), p.1006-1008

2022

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Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells

Cancer discovery, 2012-06, Vol.2 (6), p.492-494

2012

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Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications

Molecular and cellular endocrinology, 2019-10, Vol.496, p.110524-110524, Article 110524

2019

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4-LB: Feeding-Stimulated Regulation of the Epigenome Controls Adaptive Insulin Secretion

Diabetes (New York, N.Y.), 2019-06, Vol.68 (Supplement_1)

2019

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Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1700

2007

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Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels

Tissue engineering. Part C, Methods, 2018-12, Vol.24 (12), p.697

2018

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A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

Biofabrication, 2024-04, Vol.16 (2), p.25001

2024

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A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction

Biofabrication, 2024-01, Vol.16 (2)

2024

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The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet

Digestive diseases and sciences, 2008-10, Vol.53 (10), p.2761-2774

2008

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Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3352-3352

2012

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Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Endoplasmic reticulum tubules limit the size of misfolded protein condensates

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Global identification of MLL2-targeted loci reveals MLL2’s role in diverse signaling pathways

Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection

OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells

Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma

High T Gives β Cells a Boost

Mechanisms of β-cell functional adaptation to changes in workload

Sizing up beta cells made from stem cells

Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells

Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications

4-LB: Feeding-Stimulated Regulation of the Epigenome Controls Adaptive Insulin Secretion

Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction

The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet

Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem

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