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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (21), p.6625-6630

2015

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Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization

Chemical science (Cambridge), 2021-10, Vol.12 (38), p.12827-12837

2021

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STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

Nature communications, 2013-12, Vol.4 (1), p.2963, Article 2963

2013

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Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6078-6083

2012

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NMR in integrated biophysical drug discovery for RAS: past, present, and future

Journal of biomolecular NMR, 2020-11, Vol.74 (10-11), p.531-554

2020

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Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant

Journal of molecular biology, 2022-05, Vol.434 (9), p.167527-167527, Article 167527

2022

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Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3

Protein expression and purification, 2023-12, Vol.212, p.106361, Article 106361

2023

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Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

Journal of molecular biology, 2013-11, Vol.425 (21), p.4034-4046

2013

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Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)

The Journal of biological chemistry, 2016-07, Vol.291 (30), p.15641-15652

2016

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Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics

The Journal of biological chemistry, 2010-02, Vol.285 (8), p.5132-5136

2010

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Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (37), p.e2408104121

2024

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Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF

The Journal of biological chemistry, 2010-02, Vol.285 (8), p.5137-5145

2010

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Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

Proceedings of the National Academy of Sciences - PNAS, 2020-06, Vol.117 (22), p.12101-12108

2020

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Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Methods (San Diego, Calif.), 2012-08, Vol.57 (4), p.473-485

2012

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Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

Angewandte Chemie International Edition, 2020-06, Vol.59 (27), p.11037-11045

International ed. in English, 2020

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Structural features, intrinsic disorder, and modularity of a pyriform spidroin 1 core repetitive domain

Biochemistry and cell biology, 2023-08, Vol.101 (4), p.271-283

2023

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Regulation of GTPase function by autophosphorylation

Molecular cell, 2022-03, Vol.82 (5), p.950-968.e14

2022

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The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage λ Tail Tube Protein

Journal of molecular biology, 2010-10, Vol.403 (3), p.468-479

2010

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Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I

Biochemistry (Easton), 1999-06, Vol.38 (26), p.8313-8322

1999

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Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Nature communications, 2017-10, Vol.8 (1), p.1099-13, Article 1099

2017

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Protein global fold determination using site-directed spin and isotope labeling

Protein science, 2000-02, Vol.9 (2), p.302-309

2000

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Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

Angewandte Chemie, 2020-06, Vol.132 (27), p.11130-11138

2020

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Positional dependence of non-native polar mutations on folding of CFTR helical hairpins

Biochimica et biophysica acta, 2008, Vol.1778 (1), p.79-87

2008

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Effects of Troponin I Phosphorylation on Conformational Exchange in the Regulatory Domain of Cardiac Troponin C

The Journal of biological chemistry, 1999-06, Vol.274 (24), p.16681-16684

1999

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Investigating Atomic Level Structure in Pyriform Silk Proteins

Biophysical journal, 2021-02, Vol.120 (3), p.294a-294a

2021

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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

NMR in integrated biophysical drug discovery for RAS: past, present, and future

Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3

Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)

Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α

Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

Structural features, intrinsic disorder, and modularity of a pyriform spidroin 1 core repetitive domain

Regulation of GTPase function by autophosphorylation

The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage λ Tail Tube Protein

Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Protein global fold determination using site-directed spin and isotope labeling

Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

Positional dependence of non-native polar mutations on folding of CFTR helical hairpins

Effects of Troponin I Phosphorylation on Conformational Exchange in the Regulatory Domain of Cardiac Troponin C

Investigating Atomic Level Structure in Pyriform Silk Proteins

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