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Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Birthday

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.923

2021

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The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Angewandte Chemie International Edition, 2020-06, Vol.59 (26), p.10549-10556

International ed. in English, 2020

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Synthesis of a Nucleobase-Modified ProTide Library

Organic letters, 2016-11, Vol.18 (22), p.5816-5819

2016

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A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics

PloS one, 2013-01, Vol.8 (1), p.e54143

2013

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l-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2142-2146

2016

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Synthesis and Structure-Activity Relationship Studies of 2-(1,3,4-Oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as Inhibitors of DRAK2

ChemMedChem, 2014-11, Vol.9 (11), p.2587-2601

2014

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Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents

Bioorganic & medicinal chemistry letters, 2023-10, Vol.95, p.129490-129490, Article 129490

2023

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Synthesis and evaluation of isothiazolo[4,5- b ]pyridines as cyclin G-associated kinase (GAK) inhibitors

Organic & biomolecular chemistry, 2024-09, Vol.22 (36), p.7373-7389

2024

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Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3‑b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5810-5831

2019

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Discovery of Dual Death-Associated Protein Related Apoptosis Inducing Protein Kinase 1 and 2 Inhibitors by a Scaffold Hopping Approach

Journal of medicinal chemistry, 2014-09, Vol.57 (18), p.7624-7643

2014

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Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6705-6723

2018

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Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries - the Discovery of a New Class of PDE-4 Inhibitors

European Journal of Organic Chemistry, 2006-09, Vol.2006 (18), p.4257-4269

2006

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Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

Organic & biomolecular chemistry, 2016-09, Vol.14 (37), p.8743-8757

2016

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Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloropyrido[4,3- d]pyrimidine scaffold

Tetrahedron letters, 2006-12, Vol.47 (50), p.8917-8920

2006

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Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.655-668

2011

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Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.132-137

2013

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Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.145-149

2011

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The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Angewandte Chemie, 2020-06, Vol.132 (26), p.10636-10643

2020

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Anti-inflammatory activity of a pteridine derivative (4AZA2096) alleviates TNBS-induced colitis in mice

Journal of interferon & cytokine research, 2006-08, Vol.26 (8), p.575-582

2006

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Previtamin D3 with a trans-Fused Decalin CD-ring Has Pronounced Genomic Activity

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35476-35482

2003

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A Short Intramolecular Diels−Alder Route to Himbacine Derivatives

European journal of organic chemistry, 2001-08, Vol.2001 (15), p.2851-2860

2001

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Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.1909-1912

2002

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Convergent Synthesis of 1α-Hydroxyvitamin D5

European journal of organic chemistry, 2000-08, Vol.2000 (15), p.2755-2759

2000

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Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster

Chemistry & biology, 2010-02, Vol.17 (2), p.149-159

2010

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Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs

Organic & biomolecular chemistry, 2003-01, Vol.1 (2), p.257-267

2003

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Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Birthday

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Synthesis of a Nucleobase-Modified ProTide Library

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics

l-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation

Synthesis and Structure-Activity Relationship Studies of 2-(1,3,4-Oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as Inhibitors of DRAK2

Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents

Synthesis and evaluation of isothiazolo[4,5- b ]pyridines as cyclin G-associated kinase (GAK) inhibitors

Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3‑b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

Discovery of Dual Death-Associated Protein Related Apoptosis Inducing Protein Kinase 1 and 2 Inhibitors by a Scaffold Hopping Approach

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo

Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries - the Discovery of a New Class of PDE-4 Inhibitors

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloropyrido[4,3- d]pyrimidine scaffold

Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity

Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold

Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

Anti-inflammatory activity of a pteridine derivative (4AZA2096) alleviates TNBS-induced colitis in mice

Previtamin D3 with a trans-Fused Decalin CD-ring Has Pronounced Genomic Activity

A Short Intramolecular Diels−Alder Route to Himbacine Derivatives

Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists

Convergent Synthesis of 1α-Hydroxyvitamin D5

Isolation and Purification of a New Kalimantacin/Batumin-Related Polyketide Antibiotic and Elucidation of Its Biosynthesis Gene Cluster

Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs

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