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The utility of liver spheroids in addressing current issues in drug metabolism and liver toxicity evaluations

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S10-S10

Gan, Jinping

2019

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The utility of 3D hepatocyte spheroids in addressing modern problems in drug metabolism

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S15-S15

Gan, Jinping

2018

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Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization

Chemical research in toxicology, 2016-12, Vol.29 (12), p.2040-2057

2016

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Non-cytochrome P450-mediated bioactivation and its toxicological relevance

Drug metabolism reviews, 2016-11, Vol.48 (4), p.473-501

2016

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Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

The Journal of pharmacology and experimental therapeutics, 2019-01, Vol.368 (1), p.136-145

2019

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Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

Experimental biology and medicine (Maywood, N.J.), 2017-10, Vol.242 (16), p.1579-1585

2017

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Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition

Drug metabolism and disposition, 2020-08, Vol.48 (8), p.724-734

2020

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Characterization of efflux transporters involved in distribution and disposition of apixaban

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.827-835

2013

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P41 - Quantitative tissue distribution of conjugated and free payload in tumor bearing mice after intravenous dosing of glypican 3-targeting adnectiin drug conjugate

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S33-S33

2020

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Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys

Drug metabolism and disposition, 2018-02, Vol.46 (2), p.178-188

2018

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Ethylene Vinyl Alcohol Copolymer Nanofibrous Cation Exchange Chromatographic Membranes with a Gradient Porous Structure for Lysozyme Separation

Polymers, 2024-04, Vol.16 (8), p.1112

2024

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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists

The Prostate, 2011-04, Vol.71 (5), p.480-488

2011

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Untargeted analysis of protein modification by drug-related chemicals using background subtraction and proteomic approach

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S67-S67

2018

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In Vitro Screening of 50 Highly Prescribed Drugs for Thiol Adduct FormationComparison of Potential for Drug-Induced Toxicity and Extent of Adduct Formation

Chemical research in toxicology, 2009-04, Vol.22 (4), p.690-698

2009

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Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.219-226

2012

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Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration

Acta pharmaceutica Sinica. B, 2016-09, Vol.6 (5), p.460-467

2016

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Phase I Dose-Escalation Study of the Novel Antiandrogen BMS-641988 in Patients with Castration-Resistant Prostate Cancer

Clinical cancer research, 2011-02, Vol.17 (4), p.880-887

2011

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Dansyl Glutathione as a Trapping Agent for the Quantitative Estimation and Identification of Reactive Metabolites

Chemical research in toxicology, 2005-05, Vol.18 (5), p.896-903

2005

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Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.1962-1966

2010

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Repaglinide‐gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism

British journal of clinical pharmacology, 2010-12, Vol.70 (6), p.870-880

2010

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In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin

Cancer chemotherapy and pharmacology, 2012, Vol.69 (1), p.51-56

2012

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Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.891-903

2011

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A comparative transcriptome analysis focusing on immune responses of Asian swamp eel following infection with Aeromonas hydrophila

Aquaculture, 2021-06, Vol.539, p.736655, Article 736655

2021

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Alkylaniline–Hemoglobin Adducts and Risk of Non–Smoking-Related Bladder Cancer

JNCI : Journal of the National Cancer Institute, 2004-10, Vol.96 (19), p.1425-1431

2004

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Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Lab on a chip, 2020-01, Vol.2 (2), p.215-225

2020

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The utility of liver spheroids in addressing current issues in drug metabolism and liver toxicity evaluations

The utility of 3D hepatocyte spheroids in addressing modern problems in drug metabolism

Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization

Non-cytochrome P450-mediated bioactivation and its toxicological relevance

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition

Characterization of efflux transporters involved in distribution and disposition of apixaban

P41 - Quantitative tissue distribution of conjugated and free payload in tumor bearing mice after intravenous dosing of glypican 3-targeting adnectiin drug conjugate

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys

Ethylene Vinyl Alcohol Copolymer Nanofibrous Cation Exchange Chromatographic Membranes with a Gradient Porous Structure for Lysozyme Separation

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists

Untargeted analysis of protein modification by drug-related chemicals using background subtraction and proteomic approach

In Vitro Screening of 50 Highly Prescribed Drugs for Thiol Adduct FormationComparison of Potential for Drug-Induced Toxicity and Extent of Adduct Formation

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration

Phase I Dose-Escalation Study of the Novel Antiandrogen BMS-641988 in Patients with Castration-Resistant Prostate Cancer

Dansyl Glutathione as a Trapping Agent for the Quantitative Estimation and Identification of Reactive Metabolites

Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors

Repaglinide‐gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

A comparative transcriptome analysis focusing on immune responses of Asian swamp eel following infection with Aeromonas hydrophila

Alkylaniline–Hemoglobin Adducts and Risk of Non–Smoking-Related Bladder Cancer

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

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