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High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening

The Journal of biological chemistry, 2002-10, Vol.277 (40), p.37235-37241

2002

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Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

The Journal of clinical investigation, 2005-09, Vol.115 (9), p.2564-2571

2005

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Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

FEBS letters, 2001-06, Vol.499 (3), p.220-224

2001

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Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

The Journal of general physiology, 2004-08, Vol.124 (2), p.125-137

2004

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Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains

Cellular and molecular life sciences : CMLS, 2005-02, Vol.62 (4), p.446-460

2005

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Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells

American journal of physiology. Lung cellular and molecular physiology, 2006-02, Vol.290 (2), p.L242-L249

2006

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Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

Molecular pharmacology, 2005-05, Vol.67 (5), p.1797-1807

2005

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Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35079-35085

2003

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Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

FEBS letters, 2004-01, Vol.558 (1), p.52-56

2004

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Novel CFTR Chloride Channel Activators Identified by Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds

The Journal of biological chemistry, 2001-06, Vol.276 (23), p.19723-19728

2001

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Evidence against the Rescue of Defective ΔF508-CFTR Cellular Processing by Curcumin in Cell Culture and Mouse Models

The Journal of biological chemistry, 2004-09, Vol.279 (39), p.40629-40633

2004

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Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

Molecular pharmacology, 2005-12, Vol.68 (6), p.1736-1746

2005

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Regulation of taurine transport in murine macrophages

Amino acids, 2001-01, Vol.21 (2), p.151-160

2001

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IL-4 Is a Potent Modulator of Ion Transport in the Human Bronchial Epithelium In Vitro

The Journal of immunology (1950), 2002-01, Vol.168 (2), p.839-845

2002

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Gelsolin Secretion in Interleukin-4-treated Bronchial Epithelia and in Asthmatic Airways

American journal of respiratory and critical care medicine, 2005-11, Vol.172 (9), p.1090-1096

2005

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CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

American journal of physiology. Lung cellular and molecular physiology, 2003-07, Vol.285 (1), p.180-L188

2003

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Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

Journal of cell science, 2001-11, Vol.114 (Pt 22), p.4073-4081

2001

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Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.4113-4120

2003

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Identification of CFTR activators and inhibitors: chance or design?

Current opinion in pharmacology, 2004-10, Vol.4 (5), p.497-503

2004

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3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2509-2512

2003

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Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma

American journal of physiology. Lung cellular and molecular physiology, 2000-06, Vol.278 (6), p.1186-L1194

2000

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Correction of G551D‐CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB‐07

British journal of pharmacology, 2002-10, Vol.137 (4), p.504-512

2002

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Double Mechanism for Apical Tryptophan Depletion in Polarized Human Bronchial Epithelium

The Journal of immunology (1950), 2004-07, Vol.173 (1), p.542-549

2004

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Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

The Journal of biological chemistry, 1999-09, Vol.274 (39), p.27415-27425

1999

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The Importance of Differentiating Gelsolin Isoforms

American journal of respiratory and critical care medicine, 2006-03, Vol.173 (6), p.685-685a

2006

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High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening

Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells

Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating

Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

Novel CFTR Chloride Channel Activators Identified by Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds

Evidence against the Rescue of Defective ΔF508-CFTR Cellular Processing by Curcumin in Cell Culture and Mouse Models

Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

Regulation of taurine transport in murine macrophages

IL-4 Is a Potent Modulator of Ion Transport in the Human Bronchial Epithelium In Vitro

Gelsolin Secretion in Interleukin-4-treated Bronchial Epithelia and in Asthmatic Airways

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain

Identification of CFTR activators and inhibitors: chance or design?

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators

Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma

Correction of G551D‐CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB‐07

Double Mechanism for Apical Tryptophan Depletion in Polarized Human Bronchial Epithelium

Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

The Importance of Differentiating Gelsolin Isoforms

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