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Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.22-36

2004

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Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5811-5813

2009

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Epoxide-containing side chains enhance antiproliferative activity of paullones

European journal of medicinal chemistry, 2005-07, Vol.40 (7), p.655-661

2005

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A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6107-6116

2005

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A Common Pharmacophore for Epothilone and Taxanes: Molecular Basis for Drug Resistance Conferred by Tubulin Mutations in Human Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (6), p.2904-2909

2000

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Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors

Molecular pharmacology, 2002-04, Vol.61 (4), p.720-728

2002

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Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade

The Journal of biological chemistry, 2005-10, Vol.280 (40), p.34056-34062

2005

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Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Journal of medicinal chemistry, 1999-07, Vol.42 (15), p.2909-2919

1999

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Identification of small molecule inhibitors of anthrax lethal factor

Nature structural & molecular biology, 2004-01, Vol.11 (1), p.67-72

2004

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Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (11), p.2566-2569

1999

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Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics

Toxicon (Oxford), 2013-06, Vol.68, p.103-104

2013

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A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

Journal of medicinal chemistry, 2007-05, Vol.50 (9), p.2127-2136

2007

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Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site

Biochemistry (Easton), 2005-08, Vol.44 (34), p.11525-11538

2005

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A Posttranslational Modification of β-Actin Contributes to the Slow Dissociation of the Spectrin-Protein 4.1-Actin Complex of Irreversibly Sickled Cells

The Journal of cell biology, 1995-03, Vol.128 (5), p.805-818

1995

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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity

Biochemical and biophysical research communications, 2003-10, Vol.310 (1), p.84-93

2003

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Reply

Trends in pharmacological sciences (Regular ed.), 2000-09, Vol.21 (9), p.323-324

Gussio, R

2000

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Cyclin-Dependent Kinases: Initial Approaches to Exploit a Novel Therapeutic Target

Pharmacology & therapeutics (Oxford), 1999-05, Vol.82 (2), p.285-292

1999

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Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Chembiochem : a European journal of chemical biology, 2005-03, Vol.6 (3), p.541-549

2005

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Comparative electroencephalographic and behavioral effects of phencyclidine, (+)-SKF-10,047 and MK-801 in rats

The Journal of pharmacology and experimental therapeutics, 1989-12, Vol.251 (3), p.1104

1989

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Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding

Bioorganic & medicinal chemistry, 2005-01, Vol.13 (2), p.333-341

2005

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A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype a Has a Very Different Conformation Than SNAP-25 Substrate

Structure (London), 2009-05, Vol.16 (10)

2009

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Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

European journal of biochemistry, 2000-10, Vol.267 (19), p.5983-5994

2000

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Homology Model of the CDK1/cyclin B Complex

Journal of biomolecular structure & dynamics, 2005-04, Vol.22 (5), p.493-502

2005

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2-Substituted paullones : CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (6), p.567-569

2000

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An all-atom model of the pore-like structure of hexameric VP40 from Ebola: Structural insights into the monomer–hexamer transition

Journal of structural biology, 2005-07, Vol.151 (1), p.30-40

2005

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Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones

Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease

Epoxide-containing side chains enhance antiproliferative activity of paullones

A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

A Common Pharmacophore for Epothilone and Taxanes: Molecular Basis for Drug Resistance Conferred by Tubulin Mutations in Human Cancer Cells

Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors

Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade

Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Identification of small molecule inhibitors of anthrax lethal factor

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics

A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site

A Posttranslational Modification of β-Actin Contributes to the Slow Dissociation of the Spectrin-Protein 4.1-Actin Complex of Irreversibly Sickled Cells

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity

Reply

Cyclin-Dependent Kinases: Initial Approaches to Exploit a Novel Therapeutic Target

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Comparative electroencephalographic and behavioral effects of phencyclidine, (+)-SKF-10,047 and MK-801 in rats

Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype a Has a Very Different Conformation Than SNAP-25 Substrate

Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

Homology Model of the CDK1/cyclin B Complex

2-Substituted paullones : CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: Structural insights into the monomer–hexamer transition

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