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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Nature medicine, 2015-01, Vol.21 (1), p.27-36

2015

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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

Science translational medicine, 2013-10, Vol.5 (209), p.209ra151

2013

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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Journal of organic chemistry, 2017-04, Vol.82 (7), p.3506-3512

2017

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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Molecular metabolism (Germany), 2019-02, Vol.20, p.51-62

2019

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Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (10), p.2461-2466

2018

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4697-4708

2021

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Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity

Accounts of chemical research, 2017-08, Vol.50 (8), p.1855-1865

2017

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High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Organic letters, 2018-06, Vol.20 (12), p.3695-3699

2018

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Molecular metabolism (Germany), 2022-12, Vol.66, p.101638-101638, Article 101638

2022

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Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Diabetes (New York, N.Y.), 2013-05, Vol.62 (5), p.1453-1463

2013

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Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

Peptides (New York, N.Y. : 1980), 2019-10, Vol.120, p.170116-170116, Article 170116

2019

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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Nature chemical biology, 2009-10, Vol.5 (10), p.749-757

2009

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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Nature communications, 2022-11, Vol.13 (1), p.6700-14, Article 6700

2022

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Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.6134-6143

2020

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Chemical Synthesis of Insulin Analogs through a Novel Precursor

ACS chemical biology, 2014-03, Vol.9 (3), p.683-691

2014

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Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision

Organic letters, 2017-02, Vol.19 (3), p.706-709

2017

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A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

ACS chemical biology, 2019-08, Vol.14 (8), p.1829-1835

2019

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Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

ChemMedChem, 2018-04, Vol.13 (8), p.852-859

2018

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Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

Peptides (New York, N.Y. : 1980), 2018-02, Vol.100, p.18-23

2018

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A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor

Molecular metabolism (Germany), 2021-11, Vol.53, p.101316-101316, Article 101316

2021

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Peptide lipidation stabilizes structure to enhance biological function

Molecular metabolism (Germany), 2013-11, Vol.2 (4), p.468-479

2013

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Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

RSC chemical biology, 2024-07, Vol.5 (8), p.763-775

2024

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Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

Journal of peptide science, 2017-06, Vol.23 (6), p.455-465

2017

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A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Molecular metabolism (Germany), 2024-02, Vol.80, p.101863, Article 101863

2024

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Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink

Communications chemistry, 2018-06, Vol.1 (1), Article 36

2018

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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Chemical Synthesis of Insulin Analogs through a Novel Precursor

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor

Peptide lipidation stabilizes structure to enhance biological function

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink

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