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Genome mining- and synthetic biology-enabled production of hypermodified peptides

Nature chemistry, 2019-10, Vol.11 (10), p.931-939

2019

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Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Nature chemical biology, 2017-08, Vol.13 (8), p.833-835

2017

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Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6105), p.387-390

2012

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Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Current opinion in chemical biology, 2016-04, Vol.31, p.8-14

2016

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Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Nature communications, 2021-09, Vol.12 (1), p.5355-5355, Article 5355

2021

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Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Nature chemistry, 2016-11, Vol.9 (4), p.387-395

2016

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A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

Science advances, 2018-08, Vol.4 (8), p.eaat2720-eaat2720

2018

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TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes

mSystems, 2022-12, Vol.7 (6), p.e0092522

2022

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Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Nature chemistry, 2017-04, Vol.9 (4), p.387

2017

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A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (17), p.9508-9518

2020

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Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (7), p.2308-2313

2012

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Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

Journal of molecular biology, 2012-09, Vol.422 (4), p.508-518

2012

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Distinct Autocatalytic α-N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products

Journal of the American Chemical Society, 2019-06, Vol.141 (24), p.9637-9644

2019

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An Orthogonal D2O‐Based Induction System that Provides Insights into d‐Amino Acid Pattern Formation by Radical S‐Adenosylmethionine Peptide Epimerases

Angewandte Chemie International Edition, 2017-01, Vol.56 (3), p.762-766

International ed. in English, 2017

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Radical S-Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D-Amino Acid Patterns into Peptide Natural Products

Angewandte Chemie (International ed.), 2014-08, Vol.53 (32), p.8503-8507

International ed. in English, 2014

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Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

Journal of industrial microbiology & biotechnology, 2019-03, Vol.46 (3-4), p.551-563

2019

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Diverse Protein Architectures and α‑N‑Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters

ACS chemical biology, 2022-04, Vol.17 (4), p.908-917

2022

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Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (32), p.11128-11133

2008

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Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling

ACS chemical biology, 2024-05, Vol.19 (5), p.1116-1124

2024

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Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression

Methods in enzymology, 2018, Vol.604, p.259

Freeman, Michael F

2018

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An Orthogonal D 2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases

Angewandte Chemie International Edition, 2017-01, Vol.56 (3), p.762-766

2017

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Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

Journal of the American Chemical Society, 2010-01, Vol.132 (1), p.12-13

2010

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Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT

Biochemistry (Easton), 2014-07, Vol.53 (26), p.4273-4281

2014

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Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis

Chembiochem : a European journal of chemical biology, 2011-09, Vol.12 (14), p.2159-2165

2011

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RiPPing apart the rules for peptide natural products

Synthetic and systems biotechnology, 2018-06, Vol.3 (2), p.81-82

2018

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Genome mining- and synthetic biology-enabled production of hypermodified peptides

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

Distinct Autocatalytic α-N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products

An Orthogonal D2O‐Based Induction System that Provides Insights into d‐Amino Acid Pattern Formation by Radical S‐Adenosylmethionine Peptide Epimerases

Radical S-Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D-Amino Acid Patterns into Peptide Natural Products

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

Diverse Protein Architectures and α‑N‑Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling

Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression

An Orthogonal D 2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases

Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT

Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis

RiPPing apart the rules for peptide natural products

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