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A reductive aminase from Aspergillus oryzae

Nature chemistry, 2017-10, Vol.9 (10), p.961-969

2017

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The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development

JACS Au, 2023-03, Vol.3 (3), p.715-735

2023

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Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

ACS catalysis, 2016-06, Vol.6 (6), p.3880-3889

2016

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An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

ChemCatChem, 2015-02, Vol.7 (4), p.579-583

2015

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Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

Angewandte Chemie International Edition, 2017-12, Vol.56 (49), p.15589-15593

International ed. in English, 2017

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Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

ChemCatChem, 2018-02, Vol.10 (3), p.515-519

2018

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Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

ACS catalysis, 2017-01, Vol.7 (1), p.710-724

2017

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Imine reductases (IREDs)

Current opinion in chemical biology, 2017-04, Vol.37, p.19-25

2017

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Carboxylic acid reductases (CARs): An industrial perspective

Journal of biotechnology, 2019-10, Vol.304, p.78-88

2019

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Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

ACS catalysis, 2017-04, Vol.7 (4), p.2920-2925

2017

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A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

ACS catalysis, 2018-12, Vol.8 (12), p.11534-11541

2018

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One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

ACS catalysis, 2016-06, Vol.6 (6), p.3753-3759

2016

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One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N‑Heterocycles

Journal of the American Chemical Society, 2019-12, Vol.141 (49), p.19208-19213

2019

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Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

ChemCatChem, 2018-02, Vol.10 (3), p.510-514

2018

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Synthetic Approaches to the New Drugs Approved During 2022

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4376-4418

2024

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Synthetic Approaches to the New Drugs Approved During 2020

Journal of medicinal chemistry, 2022-07, Vol.65 (14), p.9607-9661

2022

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Synthetic Approaches to the New Drugs Approved during 2019

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3604-3657

2021

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A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate

ACS catalysis, 2023-02, Vol.13 (3), p.1669-1677

2023

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Synthetic Approaches to the New Drugs Approved During 2021

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10150-10201

2023

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Synthesis of 2,5‐Disubstituted Pyrrolidine Alkaloids via A One‐Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

ChemCatChem, 2018-10, Vol.10 (20), p.4733-4738

2018

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Inducing achiral aliphatic oligoureas to fold into helical conformations

Chemical communications (Cambridge, England), 2014-12, Vol.50 (95), p.15006-15009

2014

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Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)‑α-Heteroaryl Propionic Acids

Organic process research & development, 2021-03, Vol.25 (3), p.421-426

2021

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Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications

Methods in enzymology, 2018, Vol.608, p.131

2018

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Emerging Technologies for Biocatalysis in the Pharmaceutical Industry

ACS catalysis, 2023-04, Vol.13 (8), p.5571-5577

2023

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A reductive aminase from Aspergillus oryzae

The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

Imine reductases (IREDs)

Carboxylic acid reductases (CARs): An industrial perspective

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N‑Heterocycles

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

Synthetic Approaches to the New Drugs Approved During 2022

Synthetic Approaches to the New Drugs Approved During 2020

Synthetic Approaches to the New Drugs Approved during 2019

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate

Synthetic Approaches to the New Drugs Approved During 2021

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Synthesis of 2,5‐Disubstituted Pyrrolidine Alkaloids via A One‐Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

Inducing achiral aliphatic oligoureas to fold into helical conformations

Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)‑α-Heteroaryl Propionic Acids

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications

Emerging Technologies for Biocatalysis in the Pharmaceutical Industry

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