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New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

European journal of medicinal chemistry, 2016-11, Vol.124, p.82-102

2016

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Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents

Bioorganic & medicinal chemistry, 2000-05, Vol.8 (5), p.909-916

2000

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Pyrazolo[3,4-d]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1549-1561

2006

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New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase

Naunyn-Schmiedeberg's archives of pharmacology, 2003-02, Vol.367 (2), p.109-118

2003

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Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]- 1,5-diphenyl-1H-pyrazoles

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (20), p.5465-5483

2004

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Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line

European journal of medicinal chemistry, 2004-11, Vol.39 (11), p.939-946

2004

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Crystal structure of (1E,3E)-4-methylthio-2-nitro-3-phenylsulfonyl-1- pyrrolidino-1,3-butadiene, C15H18N2O4S2

Zeitschrift für Kristallographie. New crystal structures, 2003-06, Vol.218 (2), p.219-220

2003

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Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site

Journal of medicinal chemistry, 2007-06, Vol.50 (12), p.2886-2895

2007

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Modelling the interaction of steroid receptors with endocrine disrupting chemicals

BMC bioinformatics, 2005-12, Vol.6 Suppl 4 (Suppl 4), p.S10-S10, Article S10

2005

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Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone

Bioorganic & medicinal chemistry, 2003-11, Vol.11 (22), p.4749-4759

2003

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Activity of 3-carbethoxyangelicin photolysis products

Journal of photochemistry and photobiology. B, Biology, 1997-04, Vol.38 (2), p.189-195

1997

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Crystal structure of (1E,3E)-4-methylthio-2-nitro-3-phenylsulfonyl-l-pyrrolidino-1,3-butadiene,C15H18N2O4S2

Zeitschrift für Kristallographie. New crystal structures, 2003-12, Vol.218 (JG), p.231-232

2003

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Structure-Based Design, Parallel Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3858-3873

2005

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Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies

Bioorganic & medicinal chemistry, 2002-03, Vol.10 (3), p.743-751

2002

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Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1 H)-one analogs of the cardiotonic agent milrinone

European journal of pharmaceutical sciences, 2005-09, Vol.26 (1), p.78-86

2005

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Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1595-1598

2004

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Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors

Bioorganic & medicinal chemistry, 2005-02, Vol.13 (4), p.1393-1402

2005

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Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists

Journal of medicinal chemistry, 2002-10, Vol.45 (22), p.4875-4887

2002

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Developmentally Regulated Synthesis of a Low Molecular Weight Protein (Ch 21) by Differentiating Chondrocytes

The Journal of cell biology, 1988-12, Vol.107 (6), p.2455-2463

1988

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Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation

European journal of medicinal chemistry, 2004-02, Vol.39 (2), p.153-160

2004

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ω-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity

Journal of heterocyclic chemistry, 1997-05, Vol.34 (3), p.963-968

1997

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Inotropic agents. Synthesis and structure-activity relationships of new milrinone related cAMP PDE III inhibitors

Farmaco (Società chimica italiana : 1989), 1997-08, Vol.52 (8-9), p.523

1997

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New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies

Organic & biomolecular chemistry, 2005-06, Vol.3 (12), p.2262-2270

2005

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Zupan's descriptors in QSAR applied to the study of a new class of cardiotonic agents

Farmaco (Società chimica italiana : 1989), 1997-06, Vol.52 (6-7), p.411

1997

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In silico rationalization of the structural and physicochemical requirements for photobiological activity in angelicine derivatives and their heteroanalogues

Journal of computer-aided molecular design, 2003-01, Vol.17 (1), p.53

2003

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New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents

Pyrazolo[3,4-d]pyrimidines as Potent Antiproliferative and Proapoptotic Agents toward A431 and 8701-BC Cells in Culture via Inhibition of c-Src Phosphorylation

New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase

Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]- 1,5-diphenyl-1H-pyrazoles

Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line

Crystal structure of (1E,3E)-4-methylthio-2-nitro-3-phenylsulfonyl-1- pyrrolidino-1,3-butadiene, C15H18N2O4S2

Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site

Modelling the interaction of steroid receptors with endocrine disrupting chemicals

Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone

Activity of 3-carbethoxyangelicin photolysis products

Crystal structure of (1E,3E)-4-methylthio-2-nitro-3-phenylsulfonyl-l-pyrrolidino-1,3-butadiene,C15H18N2O4S2

Structure-Based Design, Parallel Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives

Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies

Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1 H)-one analogs of the cardiotonic agent milrinone

Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells

Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors

Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists

Developmentally Regulated Synthesis of a Low Molecular Weight Protein (Ch 21) by Differentiating Chondrocytes

Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation

ω-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity

Inotropic agents. Synthesis and structure-activity relationships of new milrinone related cAMP PDE III inhibitors

New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies

Zupan's descriptors in QSAR applied to the study of a new class of cardiotonic agents

In silico rationalization of the structural and physicochemical requirements for photobiological activity in angelicine derivatives and their heteroanalogues

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