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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in pharmacology, 2019-08, Vol.10, p.934-934

2019

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Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in pharmacology, 2019-08, Vol.10, p.884-884

2019

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Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide

Frontiers in physiology, 2013-01, Vol.3, p.490-490

2013

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Immunohistochemical localization of GAD67-expressing neurons and processes in the rat brainstem: Subregional distribution in the nucleus tractus solitarius

Journal of comparative neurology (1911), 2005-12, Vol.493 (2), p.274-290

2005

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Journal of pharmacological and toxicological methods, 2018-07, Vol.92, p.43-51

2018

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Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

Toxicological sciences, 2024-03, Vol.198 (2), p.316-327

2024

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Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107300-107300, Article 107300

2023

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Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats

Brain research, 2009-01, Vol.1251, p.140-150

2009

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Innovative approaches to cardiovascular safety pharmacology assessment

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107533, Article 107533

2024

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A method for assessing and monitoring consistency of nonclinical ECG analysis

Journal of pharmacological and toxicological methods, 2022-07, Vol.116, p.107189-107189, Article 107189

2022

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Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity

Journal of pharmacological and toxicological methods, 2024-05, Vol.127, p.107507-107507, Article 107507

2024

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Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107515, Article 107515

2024

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Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Journal of pharmacological and toxicological methods, 2024-03, Vol.126, p.107497-107497, Article 107497

2024

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Hindlimb unloading and female gender attenuate baroreflex-mediated sympathoexcitation

American journal of physiology. Regulatory, integrative and comparative physiology, 2005-11, Vol.289 (5), p.R1440-R1447

2005

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-05, Vol.109, p.107066-107066, Article 107066

2021

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Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Comparative medicine, 2021-04, Vol.71 (2), p.133-140

2021

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Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Journal of pharmacological and toxicological methods, 2021-11, Vol.112, p.107115-107115, Article 107115

2021

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107109-107109, Article 107109

2021

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Increased nitric oxide synthase activity and expression in the hypothalamus of hindlimb unloaded rats

Brain research, 2006-10, Vol.1115 (1), p.65-74

2006

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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

International journal of toxicology, 2020-07, Vol.39 (4), p.274-293

2020

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Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP)

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.27-37

2015

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Intravenous solid tip ECG lead placement in telemetry implanted dogs: Part 2: High quality telemetry signals yield high sensitivity to drug-induced changes

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.62-73

2013

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Multipotent adult progenitor cell lines originating from the peripheral blood of green fluorescent protein transgenic swine

Stem cells and development, 2006-08, Vol.15 (4), p.507

2006

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Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats

American journal of physiology. Regulatory, integrative and comparative physiology, 2005-07, Vol.289 (1), p.R140-R147

2005

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide

Immunohistochemical localization of GAD67-expressing neurons and processes in the rat brainstem: Subregional distribution in the nucleus tractus solitarius

The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document

Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats

Innovative approaches to cardiovascular safety pharmacology assessment

A method for assessing and monitoring consistency of nonclinical ECG analysis

Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity

Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment

Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Hindlimb unloading and female gender attenuate baroreflex-mediated sympathoexcitation

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Increased nitric oxide synthase activity and expression in the hypothalamus of hindlimb unloaded rats

An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP)

Intravenous solid tip ECG lead placement in telemetry implanted dogs: Part 2: High quality telemetry signals yield high sensitivity to drug-induced changes

Multipotent adult progenitor cell lines originating from the peripheral blood of green fluorescent protein transgenic swine

Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats

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