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Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (29), p.11663-11668

2012

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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

Nature chemical biology, 2017-09, Vol.13 (9), p.943-950

2017

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Glutamate racemase as a target for drug discovery

Microbial biotechnology, 2008-09, Vol.1 (5), p.345-360

Fisher, Stewart L.

2008

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Targeted protein degradation and the enzymology of degraders

Current opinion in chemical biology, 2018-06, Vol.44, p.47-55

2018

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Exploitation of structural and regulatory diversity in glutamate racemases

Nature, 2007-06, Vol.447 (7146), p.817-822

2007

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Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

The Journal of biological chemistry, 2013-09, Vol.288 (39), p.27960-27971

2013

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Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection

PloS one, 2014-03, Vol.9 (3), p.e90382-e90382

2014

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Conservation of the structure and function of bacterial tryptophan synthases

IUCrJ, 2019-07, Vol.6 (Pt 4), p.649-664

2019

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Translating slow-binding inhibition kinetics into cellular and in vivo effects

Nature chemical biology, 2015-06, Vol.11 (6), p.416-423

2015

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Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

ACS chemical biology, 2021-11, Vol.16 (11), p.2228-2243

2021

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A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

Chemical science (Cambridge), 2017-05, Vol.8 (5), p.3434-3443

2017

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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β‑Cell Protection

ACS chemical biology, 2016-02, Vol.11 (2), p.363-374

2016

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Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Bioorganic & medicinal chemistry, 2016-09, Vol.24 (18), p.4008-4015

2016

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Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK a: Antibacterial Agents with an Improved Safety Profile

Journal of medicinal chemistry, 2012-08, Vol.55 (15), p.6916-6933

2012

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Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

Molecular cancer therapeutics, 2021-08, Vol.20 (8), p.1367-1377

2021

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Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase

Chemical science (Cambridge), 2016-01, Vol.7 (9), p.5945-5954

2016

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Advances in Protein Degradation

SLAS discovery, 2021-04, Vol.26 (4), p.471-473

2021

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High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

SLAS discovery, 2021-04, Vol.26 (4), p.503-517

2021

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Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Communications chemistry, 2024-08, Vol.7 (1), p.183-16

2024

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Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides

Nature genetics, 1999-01, Vol.21 (1), p.119-122

1999

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Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3301-3306

2015

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A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination

SLAS discovery, 2021-04, Vol.26 (4), p.547-559

2021

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Melanocortin receptors in leptin effects

Nature (London), 1997-11, Vol.390 (6658), p.349-349

1997

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Altered Recognition Mutants of the Response Regulator PhoB: A New Genetic Strategy for Studying Protein--Protein Interactions

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (25), p.14361-14366

1996

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The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling

The Journal of biological chemistry, 1998-12, Vol.273 (52), p.34687-34690

1998

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Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

Glutamate racemase as a target for drug discovery

Targeted protein degradation and the enzymology of degraders

Exploitation of structural and regulatory diversity in glutamate racemases

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection

Conservation of the structure and function of bacterial tryptophan synthases

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β‑Cell Protection

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK a: Antibacterial Agents with an Improved Safety Profile

Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase

Advances in Protein Degradation

High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides

Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase

A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination

Melanocortin receptors in leptin effects

Altered Recognition Mutants of the Response Regulator PhoB: A New Genetic Strategy for Studying Protein--Protein Interactions

The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling

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