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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (17), p.4711-4716

2016

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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3865-3870

2014

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Structure of sugar-bound LacY

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (5), p.1784-1788

2014

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On the Mechanism of Sensing Unfolded Protein in the Endoplasmic Reticulum

Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (52), p.18773-18784

2005

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Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (29), p.9004-9009

2015

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Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10404-10410

2014

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Crystal Structure of the HIV-1 Integrase Catalytic Core and C-Terminal Domains: A Model for Viral DNA Binding

Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (15), p.8233-8238

2000

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EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (33), p.13450-13455

2011

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Crystal Structure of a ligand-bound LacY–Nanobody Complex

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (35), p.8769-8774

2018

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A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer

Biochemistry (Easton), 2018-05, Vol.57 (19), p.2786-2795

2018

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A Remote Mutation Affects the Hydride Transfer by Disrupting Concerted Protein Motions in Thymidylate Synthase

Journal of the American Chemical Society, 2012-10, Vol.134 (42), p.17722-17730

2012

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Caught in Action: X‑ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog

Biochemistry (Easton), 2021-04, Vol.60 (16), p.1243-1247

2021

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The Role of Protein Dynamics in Thymidylate Synthase Catalysis: Variants of Conserved 2‘-Deoxyuridine 5‘-Monophosphate (dUMP)-Binding Tyr-261

Biochemistry (Easton), 2006-06, Vol.45 (24), p.7415-7428

2006

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Design of potent selective zinc-mediated serine protease inhibitors

Nature (London), 1998-02, Vol.391 (6667), p.608-612

1998

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Mg2+ Binds to the Surface of Thymidylate Synthase and Affects Hydride Transfer at the Interior Active Site

Journal of the American Chemical Society, 2013-05, Vol.135 (20), p.7583-7592

2013

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Development and Binding Mode Assessment of N‑[4-[2-Propyn-1-yl[(6S)‑4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo‑3H‑cyclopenta[g]quinazolin-6-yl]amino]benzoyl]‑l‑γ-glutamyl‑d‑glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5446-5455

2013

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LpxI structures reveal how a lipid A precursor is synthesized

Nature structural & molecular biology, 2012-11, Vol.19 (11), p.1132-1138

2012

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The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition

Acta crystallographica. Section D, Biological crystallography., 2005-10, Vol.61 (10), p.1320-1334

2005

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Conformational Dynamics along an Enzymatic Reaction Pathway: Thymidylate Synthase, “the Movie”

Biochemistry (Easton), 2003-01, Vol.42 (2), p.239-247

2003

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Lessons and Conclusions from Dissecting the Mechanism of a Bisubstrate Enzyme: Thymidylate Synthase Mutagenesis, Function, and Structure

Biochemistry (Easton), 2003-01, Vol.42 (2), p.248-256

2003

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

Biochemistry (Easton), 1990-07, Vol.29 (30), p.6964-6977

1990

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Crystal Structure of an RluF–RNA Complex: A Base-Pair Rearrangement Is the Key to Selectivity of RluF for U2604 of the Ribosome

Journal of molecular biology, 2009-05, Vol.388 (4), p.785-800

2009

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Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

Science (American Association for the Advancement of Science), 1987-01, Vol.235 (4787), p.448-455

1987

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Tryptophan 80 and Leucine 143 Are Critical for the Hydride Transfer Step of Thymidylate Synthase by Controlling Active Site Access

Biochemistry (Easton), 2002-06, Vol.41 (22), p.7021-7029

2002

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Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases

Journal of molecular biology, 2001-11, Vol.313 (4), p.813-829

2001

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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Structure of sugar-bound LacY

On the Mechanism of Sensing Unfolded Protein in the Endoplasmic Reticulum

Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site

Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi

Crystal Structure of the HIV-1 Integrase Catalytic Core and C-Terminal Domains: A Model for Viral DNA Binding

EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins

Crystal Structure of a ligand-bound LacY–Nanobody Complex

A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer

A Remote Mutation Affects the Hydride Transfer by Disrupting Concerted Protein Motions in Thymidylate Synthase

Caught in Action: X‑ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog

The Role of Protein Dynamics in Thymidylate Synthase Catalysis: Variants of Conserved 2‘-Deoxyuridine 5‘-Monophosphate (dUMP)-Binding Tyr-261

Design of potent selective zinc-mediated serine protease inhibitors

Mg2+ Binds to the Surface of Thymidylate Synthase and Affects Hydride Transfer at the Interior Active Site

Development and Binding Mode Assessment of N‑[4-[2-Propyn-1-yl[(6S)‑4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo‑3H‑cyclopenta[g]quinazolin-6-yl]amino]benzoyl]‑l‑γ-glutamyl‑d‑glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells

LpxI structures reveal how a lipid A precursor is synthesized

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition

Conformational Dynamics along an Enzymatic Reaction Pathway: Thymidylate Synthase, “the Movie”

Lessons and Conclusions from Dissecting the Mechanism of a Bisubstrate Enzyme: Thymidylate Synthase Mutagenesis, Function, and Structure

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

Crystal Structure of an RluF–RNA Complex: A Base-Pair Rearrangement Is the Key to Selectivity of RluF for U2604 of the Ribosome

Atomic Structure of Thymidylate Synthase: Target for Rational Drug Design

Tryptophan 80 and Leucine 143 Are Critical for the Hydride Transfer Step of Thymidylate Synthase by Controlling Active Site Access

Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases

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