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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Nature reviews. Endocrinology, 2021-08, Vol.17 (8), p.484-495

2021

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Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

Diabetes (New York, N.Y.), 2018-12, Vol.67 (12), p.2485-2493

Finck, Brian N

2018

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Mitochondrial pyruvate transport: a historical perspective and future research directions

Biochemical journal, 2015-03, Vol.466 (3), p.443-454

2015

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

The Journal of clinical investigation, 2006-03, Vol.116 (3), p.615-622

2006

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Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Cell reports (Cambridge), 2021-01, Vol.34 (2), p.108626-108626, Article 108626

2021

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Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Cell metabolism, 2015-10, Vol.22 (4), p.682-694

2015

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Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

Immunity (Cambridge, Mass.), 2016-07, Vol.45 (1), p.60-73

2016

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Cell, 2011-08, Vol.146 (3), p.408-420

2011

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Dual function lipin proteins and glycerolipid metabolism

Trends in endocrinology and metabolism, 2011-06, Vol.22 (6), p.226-233

2011

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The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity

The Journal of biological chemistry, 2019-09, Vol.294 (36), p.13366-13377

2019

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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Science signaling, 2016-02, Vol.9 (416), p.ra21

2016

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Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction

The FEBS journal, 2021-06, Vol.288 (12), p.3784-3798

2021

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IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

Cell metabolism, 2012-10, Vol.16 (4), p.473-486

2012

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Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity

Biomolecules (Basel, Switzerland), 2020-09, Vol.10 (10), p.1386

2020

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FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (26), p.10853-10858

2009

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Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

Gastroenterology (New York, N.Y. 1943), 2009-05, Vol.136 (5), p.1552-1560

2009

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Something to mTORC About in NASH

Cellular and molecular gastroenterology and hepatology, 2022-01, Vol.13 (6), p.1843-1844

Finck, Brian N.

2022

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FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Cell metabolism, 2011-06, Vol.13 (6), p.729-738

2011

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Elevated liver glycogenolysis mediates higher blood glucose during acute exercise in Barth syndrome

PloS one, 2023-08, Vol.18 (8), p.e0290832-e0290832

2023

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The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

Biomolecules (Basel, Switzerland), 2023-01, Vol.13 (2), p.261

2023

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Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

Diabetes (New York, N.Y.), 2013-08, Vol.62 (8), p.2757-2761

2013

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Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury

Scientific reports, 2024-02, Vol.14 (1), p.3584-3584, Article 3584

2024

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Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis

PPAR research, 2022-03, Vol.2022, p.2212996-14

2022

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Loss of lipin 1‐mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice

The FASEB journal, 2019-01, Vol.33 (1), p.652-667

2019

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Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

Journal of translational medicine, 2024-07, Vol.22 (1), p.664-18, Article 664

2024

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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

Mitochondrial pyruvate transport: a historical perspective and future research directions

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Dual function lipin proteins and glycerolipid metabolism

The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

Something to mTORC About in NASH

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Elevated liver glycogenolysis mediates higher blood glucose during acute exercise in Barth syndrome

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury

Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis

Loss of lipin 1‐mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

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