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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Nature reviews. Endocrinology, 2021-08, Vol.17 (8), p.484

2021

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Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

Diabetes (New York, N.Y.), 2018-12, Vol.67 (12), p.2485-2493

Finck, Brian N

2018

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Mitochondrial pyruvate transport: a historical perspective and future research directions

Biochemical journal, 2015-03, Vol.466 (3), p.443-454

2015

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Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Cell metabolism, 2015-10, Vol.22 (4), p.682-694

2015

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Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

Immunity (Cambridge, Mass.), 2016-07, Vol.45 (1), p.60-73

2016

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Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Cell reports (Cambridge), 2021-01, Vol.34 (2), p.108626-108626, Article 108626

2021

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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Cell, 2011-08, Vol.146 (3), p.408-420

2011

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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Science signaling, 2016-02, Vol.9 (416), p.ra21

2016

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Dual function lipin proteins and glycerolipid metabolism

Trends in endocrinology and metabolism, 2011-06, Vol.22 (6), p.226-233

2011

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IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

Cell metabolism, 2012-10, Vol.16 (4), p.473-486

2012

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Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction

The FEBS journal, 2021-06, Vol.288 (12), p.3784-3798

2021

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The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity

The Journal of biological chemistry, 2019-09, Vol.294 (36), p.13366-13377

2019

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FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (26), p.10853-10858

2009

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Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

Gastroenterology (New York, N.Y. 1943), 2009-05, Vol.136 (5), p.1552-1560

2009

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FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Cell metabolism, 2011-06, Vol.13 (6), p.729-738

2011

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Something to mTORC About in NASH

Cellular and molecular gastroenterology and hepatology, 2022-01, Vol.13 (6), p.1843-1844

Finck, Brian N.

2022

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Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity

Biomolecules (Basel, Switzerland), 2020-09, Vol.10 (10), p.1386

2020

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The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

Biomolecules (Basel, Switzerland), 2023-01, Vol.13 (2), p.261

2023

Volltextzugriff (PDF)

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

Diabetes (New York, N.Y.), 2013-08, Vol.62 (8), p.2757-2761

2013

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Elevated liver glycogenolysis mediates higher blood glucose during acute exercise in Barth syndrome

PloS one, 2023-08, Vol.18 (8), p.e0290832-e0290832

2023

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Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury

Scientific reports, 2024-02, Vol.14 (1), p.3584-3584, Article 3584

2024

Volltextzugriff (PDF)

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

Journal of translational medicine, 2024-07, Vol.22 (1), p.664-18, Article 664

2024

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ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism

Journal of lipid research, 2024-02, Vol.65 (2), p.100500-100500, Article 100500

2024

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Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

Cell reports (Cambridge), 2014-06, Vol.7 (6), p.2042-2053

2014

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Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans

Journal of lipid research, 2018-09, Vol.59 (9), p.1630-1639

2018

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Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

Mitochondrial pyruvate transport: a historical perspective and future research directions

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Dual function lipin proteins and glycerolipid metabolism

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction

The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Something to mTORC About in NASH

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

Elevated liver glycogenolysis mediates higher blood glucose during acute exercise in Barth syndrome

Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans

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