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Hepatitis C Virus NS5B Polymerase Exhibits Distinct Nucleotide Requirements for Initiation and Elongation

The Journal of biological chemistry, 2008-12, Vol.283 (49), p.33893-33901

2008

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Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli

Journal of Virology, 1999-02, Vol.73 (2), p.1649-1654

1999

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De Novo Initiation of RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Journal of Virology, 2000-02, Vol.74 (4), p.2017-2022

2000

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Nature structural biology, 1999-10, Vol.6 (10), p.937-943

1999

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Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Journal of Virology, 2000-10, Vol.74 (19), p.9134-9143

2000

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Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase

Journal of Virology, 1999-12, Vol.73 (12), p.10129-10136

1999

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In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A

Antimicrobial agents and chemotherapy, 2018-11, Vol.62 (11)

2018

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Concise syntheses and HCV NS5B polymerase inhibition of (2′R)-3 and (2′S)-2′-ethynyluridine-10 and related nucleosides

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5349-5352

2017

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I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5336-5341

2011

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics

Bioorganic & medicinal chemistry, 2014-01, Vol.22 (1), p.447-458

2014

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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.2007-2017

2013

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Discovery of an irreversible HCV NS5B polymerase inhibitor

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6585-6587

2013

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.713-717

2012

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Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro- N-(( S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2119-2124

2010

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A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1030, p.81

2013

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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.466-471

2010

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Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzam ides

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2119-2124

2010

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Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

Journal of Virology, 1996-07, Vol.70 (7), p.4261-4268

1996

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Combination therapy with the farnesyl protein transferase inhibitor SCH66336 and SCH58500 (p53 adenovirus) in preclinical cancer models

Cancer research (Chicago, Ill.), 1999-12, Vol.59 (23), p.5896-5901

1999

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SCH 48973: a potent, broad-spectrum, antienterovirus compound

Antimicrobial Agents and Chemotherapy, 1997-06, Vol.41 (6), p.1220-1225

1997

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SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2

Antiviral research, 1997-08, Vol.35 (3), p.139-146

1997

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Antipicornavirus activity of SCH 47802 and analogs: in vitro and in vivo studies

Antiviral research, 1996-10, Vol.32 (2), p.71-79

1996

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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Science (American Association for the Advancement of Science), 2014-02, Vol.343 (6171), p.675-679

2014

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Geolocation Estimation of Photos Using a Hierarchical Model and Scene Classification

Computer Vision – ECCV 2018, p.575-592

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Hepatitis C Virus NS5B Polymerase Exhibits Distinct Nucleotide Requirements for Initiation and Elongation

Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli

De Novo Initiation of RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase

In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A

Concise syntheses and HCV NS5B polymerase inhibition of (2′R)-3 and (2′S)-2′-ethynyluridine-10 and related nucleosides

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

Discovery of an irreversible HCV NS5B polymerase inhibitor

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro- N-(( S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides

A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template

Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase

Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzam ides

Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

Combination therapy with the farnesyl protein transferase inhibitor SCH66336 and SCH58500 (p53 adenovirus) in preclinical cancer models

SCH 48973: a potent, broad-spectrum, antienterovirus compound

SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2

Antipicornavirus activity of SCH 47802 and analogs: in vitro and in vivo studies

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

Geolocation Estimation of Photos Using a Hierarchical Model and Scene Classification

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