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Ketone therapy for heart failure: current evidence for clinical use

Cardiovascular research, 2022-03, Vol.118 (4), p.977-987

2022

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Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

PloS one, 2012-04, Vol.7 (4), p.e36200

2012

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The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis

Inflammation research, 2020-06, Vol.69 (6), p.549-558

2020

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A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Nature communications, 2024-01, Vol.15 (1), p.334-334, Article 334

2024

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Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Cell reports (Cambridge), 2015-10, Vol.13 (1), p.157-167

2015

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SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

Scientific reports, 2017-03, Vol.7 (1), p.248-248, Article 248

2017

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (7), p.2376-2381

2012

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Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling

BMC cancer, 2020-08, Vol.20 (1), p.751-13, Article 751

2020

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Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

Diabetes (New York, N.Y.), 2008-05, Vol.57 (5), p.1205-1215

2008

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Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart

ESC Heart Failure, 2021-12, Vol.8 (6), p.5606-5612

2021

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Metabolomic Fingerprint of Behavioral Changes in Response to Full-Spectrum Cannabis Extracts

Frontiers in pharmacology, 2022-01, Vol.13, p.831052-831052

2022

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A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

Physiological reports, 2019-10, Vol.7 (19), p.e14250-n/a

2019

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Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

Physiological reports, 2020-04, Vol.8 (8), p.e14420-n/a

2020

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ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis

The EMBO journal, 2006-03, Vol.25 (5), p.977-986

2006

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PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Molecular metabolism (Germany), 2016-07, Vol.5 (7), p.459-471

2016

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Toward Connecting Metabolism to the Exocytotic Site

Trends in cell biology, 2017-03, Vol.27 (3), p.163-171

2017

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The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation

Biochimica et biophysica acta. Molecular basis of disease, 2020-07, Vol.1866 (7), p.165771-165771, Article 165771

2020

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Ketone therapy reduces cardiac inflammation and cardiac dysfunction in sepsis

Journal of molecular and cellular cardiology, 2022-12, Vol.173, p.1-2

2022

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Sa1537: EMPAGLIFOZIN IMPROVES GASTROINTESTINAL INFLAMMATION IN A MOUSE MODEL OF COLITIS INDEPENDENT OF CHANGES TO GUT MICROBIAL COMPOSITION

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-406-S-406

2022

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Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity

Journal of Diabetes Research, 2016-01, Vol.2016, p.9158562-9

2016

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Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression

Journal of molecular endocrinology, 2011-12, Vol.47 (3), p.273-283

2011

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Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

Circulation. Heart failure, 2020-01, Vol.13 (1), p.e006277-e006277

2020

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Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Canadian journal of diabetes, 2012-10, Vol.36 (5), p.275-280

2012

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Empagliflozin suppresses inflammation and protects against acute septic renal injury

Inflammopharmacology, 2021-02, Vol.29 (1), p.269-279

2021

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Resveratrol reduces cardiac NLRP3‐inflammasome activation and systemic inflammation to lessen doxorubicin‐induced cardiotoxicity in juvenile mice

FEBS letters, 2021-06, Vol.595 (12), p.1681-1695

2021

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Ketone therapy for heart failure: current evidence for clinical use

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling

Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart

Metabolomic Fingerprint of Behavioral Changes in Response to Full-Spectrum Cannabis Extracts

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis

PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Toward Connecting Metabolism to the Exocytotic Site

The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation

Ketone therapy reduces cardiac inflammation and cardiac dysfunction in sepsis

Sa1537: EMPAGLIFOZIN IMPROVES GASTROINTESTINAL INFLAMMATION IN A MOUSE MODEL OF COLITIS INDEPENDENT OF CHANGES TO GUT MICROBIAL COMPOSITION

Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity

Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

Empagliflozin suppresses inflammation and protects against acute septic renal injury

Resveratrol reduces cardiac NLRP3‐inflammasome activation and systemic inflammation to lessen doxorubicin‐induced cardiotoxicity in juvenile mice

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