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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Nature communications, 2021-05, Vol.12 (1), p.2656-2656, Article 2656

2021

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SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

Cancer discovery, 2018-10, Vol.8 (10), p.1237-1249

2018

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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

The Journal of experimental medicine, 2021-01, Vol.218 (1)

2021

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IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels

PloS one, 2013-10, Vol.8 (10), p.e76513-e76513

2013

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Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

Oncotarget, 2015-06, Vol.6 (16), p.14318-14328

2015

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Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors

Breast cancer research and treatment, 2012-06, Vol.133 (2), p.511-521

2012

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Effects of a human compact anti-ErbB2 antibody on gastric cancer

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014, Vol.17 (1), p.107-115, Article 107

2014

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The αvβ6 Integrin Is Transferred Intercellularly via Exosomes

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4545-4551

2015

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Exosome-mediated Transfer of alpha v beta 3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype

Molecular cancer research, 2016-11, Vol.14 (11), p.1136-1146

2016

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Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype

Molecular cancer research, 2016-11, Vol.14 (11), p.1136-1146

2016

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Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Cancer discovery, 2022-01, Vol.12 (1), p.47-61

2022

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Cancer discovery, 2022-06, Vol.12 (6), p.1500-1517

2022

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Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

Matrix biology, 2019-04, Vol.77, p.41-57

2019

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CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer

Cancer research (Chicago, Ill.), 2023-12, Vol.83 (24), p.4130-4141

2023

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Abstract LB-338: SHP2 inhibition enhances sensitivity to MEK inhibitors in multiple resistant cancer models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-338-LB-338

2018

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Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

Matrix biology, 2018-09, Vol.70, p.20-35

2018

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Abstract 357: Exosome-mediated transfer of alphaV integrins promotes prostate cancer cell-cell communication

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.357-357

2015

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Mechanisms of cardiotoxicity associated with ErbB2 inhibitors

Breast cancer research and treatment, 2012-07, Vol.134 (2), p.595-602

2012

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αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor

Cancer research (Chicago, Ill.), 2016-09, Vol.76 (17), p.5163-5174

2016

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αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression

Biochemical journal, 2015-03, Vol.466 (3), p.525-536

2015

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Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Non-Tumorigenic Cells Promotes a Migratory Phenotype

Molecular cancer research, 2016-07, Vol.14 (11), p.1136-1146

2016

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Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

Cancer discovery, 2021-08, Vol.12 (1), p.47-61

2021

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IGF-IR Promotes Prostate Cancer Growth by Stabilizing [alpha].sub.5[beta].sub.1 Integrin Protein Levels

PloS one, 2013-10, Vol.8 (10), p.e76513

2013

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Exosomal avß6 integrin is required for monocyte M2 polarization in prostate cancer

Matrix biology, 2018-09, Vol.70, p.20

2018

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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors

Effects of a human compact anti-ErbB2 antibody on gastric cancer

The αvβ6 Integrin Is Transferred Intercellularly via Exosomes

Exosome-mediated Transfer of alpha v beta 3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer

Abstract LB-338: SHP2 inhibition enhances sensitivity to MEK inhibitors in multiple resistant cancer models

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

Abstract 357: Exosome-mediated transfer of alphaV integrins promotes prostate cancer cell-cell communication

Mechanisms of cardiotoxicity associated with ErbB2 inhibitors

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor

αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Non-Tumorigenic Cells Promotes a Migratory Phenotype

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

IGF-IR Promotes Prostate Cancer Growth by Stabilizing [alpha].sub.5[beta].sub.1 Integrin Protein Levels

Exosomal avß6 integrin is required for monocyte M2 polarization in prostate cancer

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