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Development of synthetic lethality anticancer therapeutics

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.7859-7873

Fang, Bingliang

2014

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mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Nature communications, 2021-03, Vol.12 (1), p.1589-1589, Article 1589

2021

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RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies

Acta biochimica et biophysica Sinica, 2016-01, Vol.48 (1), p.27-38

Fang, Bingliang

2016

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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Nature cell biology, 2020-04, Vol.22 (4), p.476

2020

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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma

The New England journal of medicine, 2013-08, Vol.369 (6), p.507-516

2013

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Introduction to this Special Issue: “Biomarker Discovery and Precision Medicine”

Journal of cancer metastasis and treatment, 2020-01, Vol.2020

Fang, Bingliang

2020

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Genetic Interactions of STAT3 and Anticancer Drug Development

Cancers, 2014-03, Vol.6 (1), p.494-525

Fang, Bingliang

2014

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Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case Severity

Frontiers in microbiology, 2020-10, Vol.11

2020

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Mechanisms of resistance to TRAIL-induced apoptosis in cancer

Cancer gene therapy, 2005-03, Vol.12 (3), p.228-237

2005

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Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance

BMC cancer, 2018-11, Vol.18 (1), p.1082-1082, Article 1082

2018

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B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy

Clinical cancer research, 2017-08, Vol.23 (15), p.4212-4223

2017

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Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations

Scientific reports, 2022-01, Vol.12 (1), p.1248-1248, Article 1248

2022

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An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

Cancer immunology research, 2019-08, Vol.7 (8), p.1267-1279

2019

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CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

Scientific reports, 2022-07, Vol.12 (1), p.12984-10, Article 12984

2022

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Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

Oncotarget, 2016-01, Vol.7 (3), p.3548-3558

2016

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Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells

Journal of medicinal chemistry, 2008-03, Vol.51 (5), p.1242-1251

2008

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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Oncogene, 2020-01, Vol.39 (4), p.801-813

2020

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Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer

Cancer letters, 2015-02, Vol.357 (1), p.179-185

2015

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A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers

Molecular cancer therapeutics, 2021-03, Vol.20 (3), p.477-489

2021

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Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene-Armed, Telomerase-Specific Oncolytic Adenovirus

Clinical cancer research, 2008-05, Vol.14 (9), p.2813-2823

2008

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Therapy-Resistant Cancer Stem Cells Have Differing Sensitivity to Photon versus Proton Beam Radiation

Journal of thoracic oncology, 2013-12, Vol.8 (12), p.1484-1491

2013

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Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo

PloS one, 2010-11, Vol.5 (11), p.e14124

2010

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STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

Cancer research (Chicago, Ill.), 2011-05, Vol.71 (10), p.3658-3668

2011

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Development of synthetic lethality anticancer therapeutics

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma

Introduction to this Special Issue: “Biomarker Discovery and Precision Medicine”

Genetic Interactions of STAT3 and Anticancer Drug Development

Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case Severity

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance

Structure-based classification predicts drug response in EGFR-mutant NSCLC

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy

Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells

Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer

A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers

Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene-Armed, Telomerase-Specific Oncolytic Adenovirus

Therapy-Resistant Cancer Stem Cells Have Differing Sensitivity to Photon versus Proton Beam Radiation

Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo

STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

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