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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Molecular pharmaceutics, 2020-11, Vol.17 (11), p.4114-4124

2020

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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Drug metabolism and disposition, 2020-07, Vol.48 (7), p.528-536

2020

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Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites

Drug metabolism and pharmacokinetics, 2019-10, Vol.34 (5), p.308-316

2019

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Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance

Drug metabolism and disposition, 2002-06, Vol.30 (6), p.694-700

2002

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Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.109-119

2019

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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species

Drug metabolism and disposition, 2022-03, Vol.50 (3), p.197-203

2022

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Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1253-1261

2016

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Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

Drug metabolism letters, 2016-06, Vol.10 (2), p.136-143

2016

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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Bioorganic & medicinal chemistry letters, 2023-06, Vol.89, p.129277-129277, Article 129277

2023

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Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

Drug metabolism letters, 2016-06, Vol.10 (2), p.91-100

2016

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Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

ACS medicinal chemistry letters, 2021-09, Vol.12 (9), p.1380-1388

2021

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Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection

Journal of aerosol medicine and pulmonary drug delivery, 2019-10, Vol.32 (5), p.251-265

2019

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Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

Journal of medicinal chemistry, 2015-06, Vol.58 (12), p.5121-5136

2015

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Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.891

2001

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Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone

Chemical research in toxicology, 2000-01, Vol.13 (1), p.53-62

2000

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Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.28-36

2003

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP

Bioorganic & medicinal chemistry letters, 2014-07, Vol.24 (13), p.2877-2880

2014

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Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.925-929

2015

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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery

Future medicinal chemistry, 2014-01, Vol.6 (18), p.1995-2012

2014

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Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver

Xenobiotica, 2013-03, Vol.43 (3), p.236-245

2013

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Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition

Chemical research in toxicology, 2011-10, Vol.24 (10), p.1668-1677

2011

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Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.841-850

2010

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4-Hydroxylated Metabolites of the Antiestrogens Tamoxifen and Toremifene Are Metabolized to Unusually Stable Quinone Methides

Chemical research in toxicology, 2000-01, Vol.13 (1), p.45-52

2000

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Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.297-297

2021

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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human

Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine

Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites

Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance

Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations

Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA

Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone

Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor

Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery

Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver

Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition

Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction

4-Hydroxylated Metabolites of the Antiestrogens Tamoxifen and Toremifene Are Metabolized to Unusually Stable Quinone Methides

Abstract 297: Innovation in delivering synthetically challenging bicyclic arginase inhibitors to enhance immunotherapy

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