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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

The New England journal of medicine, 2023-02, Vol.388 (5), p.395-405

2023

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Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers

Hypertension research, 2023-01, Vol.46 (1), p.108-118

2023

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Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

Arteriosclerosis, thrombosis, and vascular biology, 2009-01, Vol.29 (1), p.19-26

2009

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

Nature medicine, 2004-04, Vol.10 (4), p.416-421

2004

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Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49982-49988

2002

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Nature immunology, 2000-11, Vol.1 (5), p.398-401

2000

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ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters

The Journal of biological chemistry, 2008-12, Vol.283 (52), p.36624-36635

2008

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Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2015-07, Vol.314 (2), p.151

2015

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ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol

Journal of lipid research, 2007-03, Vol.48 (3), p.621-632

2007

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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

Physiological genomics, 2004-11, Vol.19 (3), p.319-330

2004

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Local Injection of Bevacizumab (Avastin) and Angiolytic KTP Laser Treatment of Recurrent Respiratory Papillomatosis of the Vocal Folds: A Prospective Study

Annals of otology, rhinology & laryngology, 2011-10, Vol.120 (10), p.627-634

2011

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Scavenger receptors in atherosclerosis: beyond lipid uptake

Arteriosclerosis, thrombosis, and vascular biology, 2006-08, Vol.26 (8), p.1702-1711

2006

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Results from a Randomized, Open-Label, Crossover Study Evaluating Pharmacokinetic Interaction Between the Aldosterone Synthase Inhibitor Baxdrostat and Metformin in Healthy Human Subjects

The American heart journal, 2022-12, Vol.254, p.245-245

2022

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Baxdrostat for Treatment-Resistant Hypertension. Reply

The New England journal of medicine, 2023-05, Vol.388 (19), p.1821-1822

2023

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Safety and Dosing of Bevacizumab (Avastin) for the Treatment of Recurrent Respiratory Papillomatosis

Annals of otology, rhinology & laryngology, 2012-09, Vol.121 (9), p.587-593

2012

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Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I

The Journal of biological chemistry, 2002-09, Vol.277 (36), p.33178-33187

2002

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Abca7 Null Mice Retain Normal Macrophage Phosphatidylcholine and Cholesterol Efflux Activity despite Alterations in Adipose Mass and Serum Cholesterol Levels

The Journal of biological chemistry, 2005-02, Vol.280 (5), p.3989-3995

2005

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Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury

Infection and Immunity, 2005-03, Vol.73 (3), p.1754-1763

2005

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Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment

Circulation (New York, N.Y.), 2005-07, Vol.112 (4), p.578-586

2005

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Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2023-05, Vol.23 (3), p.277-286

2023

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Cross-Linking and Lipid Efflux Properties of ApoA-I Mutants Suggest Direct Association between ApoA-I Helices and ABCA1

Biochemistry (Easton), 2004-02, Vol.43 (7), p.2126-2139

2004

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An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience

Journal of clinical and translational science, 2021, Vol.5 (1), p.e137-e137, Article e137

2021

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Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD

American journal of kidney diseases, 2019-09, Vol.74 (3), p.328-337

2019

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Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia

Kidney international, 2015-12, Vol.88 (6), p.1427-1433

2015

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Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function

Journal of lipid research, 2014-03, Vol.55 (3), p.493-503

2014

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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters

Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

Local Injection of Bevacizumab (Avastin) and Angiolytic KTP Laser Treatment of Recurrent Respiratory Papillomatosis of the Vocal Folds: A Prospective Study

Scavenger receptors in atherosclerosis: beyond lipid uptake

Results from a Randomized, Open-Label, Crossover Study Evaluating Pharmacokinetic Interaction Between the Aldosterone Synthase Inhibitor Baxdrostat and Metformin in Healthy Human Subjects

Baxdrostat for Treatment-Resistant Hypertension. Reply

Safety and Dosing of Bevacizumab (Avastin) for the Treatment of Recurrent Respiratory Papillomatosis

Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I

Abca7 Null Mice Retain Normal Macrophage Phosphatidylcholine and Cholesterol Efflux Activity despite Alterations in Adipose Mass and Serum Cholesterol Levels

Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment

Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects

Cross-Linking and Lipid Efflux Properties of ApoA-I Mutants Suggest Direct Association between ApoA-I Helices and ABCA1

An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience

Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD

Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia

Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function

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