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The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

Cancer research (Chicago, Ill.), 2014-07, Vol.74 (13), p.3579-3590

2014

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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4410-E4417

2015

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The Hedgehog Signaling Pathway in Cancer

Clinical cancer research, 2006-10, Vol.12 (20), p.5924-5928

2006

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Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting

BMC cancer, 2023-04, Vol.23 (1), p.352-352, Article 352

2023

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Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

Molecular and Cellular Biology, 2010-04, Vol.30 (8), p.1910-1922

2010

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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

Cell metabolism, 2018-09, Vol.28 (3), p.383-399.e9

2018

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Formins: signaling effectors for assembly and polarization of actin filaments

Journal of cell science, 2003-07, Vol.116 (Pt 13), p.2603-2611

2003

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An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Cancer research (Chicago, Ill.), 2012-11, Vol.72 (22), p.5812-5823

2012

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A specificity map for the PDZ domain family

PLoS biology, 2008-09, Vol.6 (9), p.e239-e239

2008

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The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

Current biology, 2009-08, Vol.19 (15), p.1320-1326

2009

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A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC

PloS one, 2018-06, Vol.13 (6), p.e0199264-e0199264

2018

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AKT-induced tamoxifen resistance is overturned by RRM2 inhibition

Molecular cancer research, 2014-03, Vol.12 (3), p.394-407

2014

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DNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non―Small Cell Lung Cancer

Clinical cancer research, 2012-04, Vol.18 (8), p.2360-2373

2012

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Formin Leaky Cap Allows Elongation in the Presence of Tight Capping Proteins

Current biology, 2003-10, Vol.13 (20), p.1820-1823

2003

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Mechanism of Formin-Induced Nucleation of Actin Filaments

Biochemistry (Easton), 2003-01, Vol.42 (2), p.486-496

2003

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A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules

Science (American Association for the Advancement of Science), 2002-01, Vol.295 (5553), p.321-324

2002

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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

Science signaling, 2008-09, Vol.1 (39), p.ra7

2008

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Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism

Molecules, 2012-11, Vol.17 (11), p.13098-13115

2012

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Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus

Molecular and Cellular Biology, 2005-08, Vol.25 (16), p.7054-7068

2005

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Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

Science (American Association for the Advancement of Science), 1997-04, Vol.276 (5309), p.118-122

1997

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mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

Cancer cell, 2016-04, Vol.29 (4), p.548-562

2016

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Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p

The Journal of cell biology, 1999-03, Vol.144 (5), p.947-961

1999

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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

The Journal of biological chemistry, 2018-10, Vol.293 (41), p.15947-15961

2018

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Abstract 2917: High complexity molecular indexing reveals that time-dependent cell plasticity underpins response to EGFR targeted therapy

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2917-2917

2017

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The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

The Hedgehog Signaling Pathway in Cancer

Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting

Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

Formins: signaling effectors for assembly and polarization of actin filaments

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

A specificity map for the PDZ domain family

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC

AKT-induced tamoxifen resistance is overturned by RRM2 inhibition

DNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non―Small Cell Lung Cancer

Formin Leaky Cap Allows Elongation in the Presence of Tight Capping Proteins

Mechanism of Formin-Induced Nucleation of Actin Filaments

A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism

Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus

Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

Abstract 2917: High complexity molecular indexing reveals that time-dependent cell plasticity underpins response to EGFR targeted therapy

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