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Structure of the homodimeric androgen receptor ligand-binding domain

Nature communications, 2017-02, Vol.8 (1), p.14388-14388, Article 14388

2017

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EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

ACS chemical biology, 2016-09, Vol.11 (9), p.2499-2505

2016

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Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts

Protein science, 2023-04, Vol.32 (4), p.e4553-n/a

2023

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Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (13), p.e2023784119-e2023784119

2022

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Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways

International journal of molecular sciences, 2021-09, Vol.22 (18), p.10049

2021

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Advances in our structural understanding of orphan nuclear receptors

Trends in biochemical sciences (Amsterdam. Regular ed.), 2015-01, Vol.40 (1), p.25-35

2015

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Diversity of Quaternary Structures Regulates Nuclear Receptor Activities

Trends in biochemical sciences (Amsterdam. Regular ed.), 2019-01, Vol.44 (1), p.2-6

2019

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Topological dynamics of an intrinsically disordered N‐terminal domain of the human androgen receptor

Protein science, 2022-06, Vol.31 (6), p.e4334-n/a

2022

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The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes

The FASEB journal, 2023-01, Vol.37 (1), p.e22709-n/a

2023

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Coregulator Control of Androgen Receptor Action by a Novel Nuclear Receptor-binding Motif

The Journal of biological chemistry, 2014-03, Vol.289 (13), p.8839-8851

2014

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Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

Endocrine-related cancer, 2019-08, Vol.26 (8), p.R479-R497

2019

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The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities

Nucleic acids research, 2022-12, Vol.50 (22), p.13063-13082

2022

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Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

Structure (London), 2018-01, Vol.26 (1), p.145-152.e3

2018

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surface on the androgen receptor that allosterically regulates coactivator binding

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (41), p.16074-16079

2007

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Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

Molecular endocrinology (Baltimore, Md.), 2012-07, Vol.26 (7), p.1078-1090

2012

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The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function

PloS one, 2012-06, Vol.7 (6), p.e37963-e37963

2012

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Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor

Molecular endocrinology (Baltimore, Md.), 2007-12, Vol.21 (12), p.2919-2928

2007

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Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development

Seminars in cancer biology, 2021-08, Vol.73, p.58-75

2021

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A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

Molecular and cellular endocrinology, 2012-01, Vol.348 (2), p.394-402

2012

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Allosteric mechanisms of nuclear receptors: insights from computational simulations

Molecular and cellular endocrinology, 2014-08, Vol.393 (1-2), p.75-82

2014

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A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance

Science advances, 2023-03, Vol.9 (11), p.eade2175-eade2175

2023

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The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.8060-8068

2005

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6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5856-5860

2008

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Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

Nature reviews. Endocrinology, 2020-07, Vol.16 (7), p.363-377

2020

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Structure of the homodimeric androgen receptor ligand-binding domain

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

Structure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways

Advances in our structural understanding of orphan nuclear receptors

Diversity of Quaternary Structures Regulates Nuclear Receptor Activities

Topological dynamics of an intrinsically disordered N‐terminal domain of the human androgen receptor

The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes

Coregulator Control of Androgen Receptor Action by a Novel Nuclear Receptor-binding Motif

Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

surface on the androgen receptor that allosterically regulates coactivator binding

Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function

Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor

Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control

Allosteric mechanisms of nuclear receptors: insights from computational simulations

A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance

The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor

γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

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