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Targeting mutant p53 for efficient cancer therapy

Nature reviews. Cancer, 2018-02, Vol.18 (2), p.89

2018

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A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

EMBO molecular medicine, 2021-02, Vol.13 (2), p.e10852-n/a

2021

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High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

Free radical biology & medicine, 2009-12, Vol.47 (11), p.1661-1671

2009

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Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Nature communications, 2015-03, Vol.6 (1), p.6479-6479, Article 6479

2015

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Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Cell death & disease, 2021-07, Vol.12 (7), p.709-10, Article 709

2021

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Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Cell death & disease, 2022-08, Vol.13 (8), p.672-672, Article 672

2022

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Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

Biochimica et biophysica acta, 2014-07, Vol.1840 (7), p.2105-2111

2014

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Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

Free radical biology & medicine, 2008-08, Vol.45 (4), p.494-502

2008

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p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

Cell cycle (Georgetown, Tex.), 2009-11, Vol.8 (21), p.3584-3591

2009

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Wig-1 Dependent Regulation of Cellular AntioxidantProteins and Connections to P53

Free radical biology & medicine, 2015-10, Vol.87, p.S66

2015

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130 - Wig-1 Dependent Regulation of Cellular AntioxidantProteins and Connections to P53

Free radical biology & medicine, 2015-10, Vol.87, p.S66-S66

2015

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Impact of combined MRP1 inhibition and mutant p53-targeting compound APR-246

JOURNAL OF CLINICAL ONCOLOGY, 2019, Vol.37 (15_suppl), p.e14712-e14712

2019

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A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

Free radical biology & medicine, 2013-10, Vol.63, p.369-380

2013

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Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Free radical biology & medicine, 2012-02, Vol.52 (4), p.803-810

2012

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Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Free radical biology & medicine, 2014-04, Vol.69, p.67

2014

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Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Free radical biology & medicine, 2014-04, Vol.69, p.67-76

2014

Volltextzugriff (PDF)

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

JNCI : Journal of the National Cancer Institute, 2009-01, Vol.101 (1), p.37-47

2009

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Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

Oncotarget, 2016-01, Vol.7 (2), p.1895-1911

2016

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Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1

Experimental cell research, 2009-05, Vol.315 (8), p.1360-1371

2009

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Thioredoxin Reductase as a Target Enzyme for Electrophilic Anticancer Drugs

Eriksson, Sofi

2011

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Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments

Journal of cell science, 2004-02, Vol.117 (Pt 6), p.919-932

2004

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Increasing melanoma incidence and survival trend shifts with improved melanoma-specific survival between 1990 and 2020 in Sweden

British journal of dermatology (1951), 2023-11, Vol.189 (6), p.702-709

2023

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Loss in life expectancy in patients with stage II-III cutaneous melanoma in Sweden: A population-based cohort study

Journal of the American Academy of Dermatology, 2024-05, Vol.90 (5), p.963-969

2024

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Greater decreases in cholesterol levels among individuals with high cardiovascular risk than among the general population: the northern Sweden MONICA study 1994 to 2014

European heart journal, 2016-07, Vol.37 (25), p.1985-1992

2016

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Drug Repurposing

1, 2023

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Targeting mutant p53 for efficient cancer therapy

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Correction: Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

Wig-1 Dependent Regulation of Cellular AntioxidantProteins and Connections to P53

130 - Wig-1 Dependent Regulation of Cellular AntioxidantProteins and Connections to P53

Impact of combined MRP1 inhibition and mutant p53-targeting compound APR-246

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1

Thioredoxin Reductase as a Target Enzyme for Electrophilic Anticancer Drugs

Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments

Increasing melanoma incidence and survival trend shifts with improved melanoma-specific survival between 1990 and 2020 in Sweden

Loss in life expectancy in patients with stage II-III cutaneous melanoma in Sweden: A population-based cohort study

Greater decreases in cholesterol levels among individuals with high cardiovascular risk than among the general population: the northern Sweden MONICA study 1994 to 2014

Drug Repurposing

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