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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Nature cell biology, 2014-11, Vol.16 (11), p.1069-1079

2014

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Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism

Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (41), p.E6064-E6071

2016

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Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies

Biochemical journal, 2006-11, Vol.400 (1), p.105-114

2006

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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3078-3083

2011

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Discovery of a potent and selective Aurora kinase inhibitor

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4880-4884

2008

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Structure-Guided Engineering of Xylitol Dehydrogenase Cosubstrate Specificity

Structure (London), 2006-03, Vol.14 (3), p.567-575

2006

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Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.37-41

2015

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Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands

Acta crystallographica. Section D, Biological crystallography., 2008-09, Vol.64 (9), p.909-918

2008

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Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use

Biochemistry (Easton), 2004-02, Vol.43 (4), p.879-889

2004

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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5186-5189

2008

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2-Aminobenzimidazoles as potent Aurora kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5158-5161

2009

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5648-5652

2008

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Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Journal of molecular biology, 2017-06, Vol.429 (11), p.1684-1704

2017

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Mouse Aurora A: Expression in Escherichia coli and purification

Protein expression and purification, 2007-07, Vol.54 (1), p.139-146

2007

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Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2938-2942

2005

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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (3), p.742-746

2016

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Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8503-8516

2014

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Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

Acta crystallographica. Section F, Structural biology and crystallization communications, 2008-08, Vol.64 (8), p.686-691

2008

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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.42-46

2015

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An evaluation of emergency medical technicians' ability to use manual ventilation devices

Annals of emergency medicine, 1983-12, Vol.12 (12), p.765-768

1983

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Two-tailed RT-qPCR: a novel method for highly accurate miRNA quantification

Nucleic acids research, 2017-09, Vol.45 (15), p.e144-e144

2017

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Managing the Response to Disasters Using Microcomputers

Interfaces (Providence), 1984-03, Vol.14 (2), p.29-39

1984

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Does ‘Strong Analgesic’ Equal ‘Strong Opioid’? Tapentadol and the Concept of ‘µ-Load’

Advances in therapy, 2018-10, Vol.35 (10), p.1471-1484

2018

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Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement

Critical care medicine, 2015-06, Vol.43 (6), p.1291-1325

2015

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism

Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Discovery of a potent and selective Aurora kinase inhibitor

Structure-Guided Engineering of Xylitol Dehydrogenase Cosubstrate Specificity

Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors

Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands

Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

2-Aminobenzimidazoles as potent Aurora kinase inhibitors

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes

Mouse Aurora A: Expression in Escherichia coli and purification

Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors

An evaluation of emergency medical technicians' ability to use manual ventilation devices

Two-tailed RT-qPCR: a novel method for highly accurate miRNA quantification

Managing the Response to Disasters Using Microcomputers

Does ‘Strong Analgesic’ Equal ‘Strong Opioid’? Tapentadol and the Concept of ‘µ-Load’

Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement

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