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Progress towards a public chemogenomic set for protein kinases and a call for contributions

PloS one, 2017-08, Vol.12 (8), p.e0181585-e0181585

2017

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Nature chemical biology, 2016-10, Vol.12 (10), p.876-884

2016

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Updated protein domain annotation of the PARP protein family sheds new light on biological function

Nucleic acids research, 2023-08, Vol.51 (15), p.8217-8236

2023

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Nature (London), 2014-04, Vol.508 (7495), p.222-227

2014

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Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Structure (London), 2013-06, Vol.21 (6), p.986-996

2013

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Comprehensive characterization of the Published Kinase Inhibitor Set

Nature biotechnology, 2016, Vol.34 (1), p.95-103

2016

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Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

Angewandte Chemie International Edition, 2017-05, Vol.56 (22), p.6264-6267

International ed. in English, 2017

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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9312-9330

2012

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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

Nature communications, 2019-07, Vol.10 (1), p.3166-11, Article 3166

2019

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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2830-2836

2019

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The Intersection of Structural and Chemical Biology - An Essential Synergy

Cell chemical biology, 2016-01, Vol.23 (1), p.173-182

2016

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Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17237-17242

2006

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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

Biochemical journal, 2014-12, Vol.464 (2), p.231-239

2014

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Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

ChemMedChem, 2018-01, Vol.13 (1), p.48-66

2018

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4016

2019

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Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

ACS chemical biology, 2015-01, Vol.10 (1), p.310-319

2015

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Crystal structure of human RIOK2 bound to a specific inhibitor

Open biology, 2019-04, Vol.9 (4), p.190037-190037

2019

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Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships

ChemMedChem, 2020-01, Vol.15 (1), p.26-49

2020

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Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

The Journal of biological chemistry, 2002-07, Vol.277 (29), p.26351-26355

2002

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NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Scientific reports, 2017-07, Vol.7 (1), p.5445-13, Article 5445

2017

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Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Organic & biomolecular chemistry, 2017, Vol.15 (40), p.8655-8660

2017

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Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

Angewandte Chemie (International ed.), 2013-11, Vol.52 (46), p.12187-12191

International ed. in English, 2013

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The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity

Frontiers in plant science, 2019-09, Vol.10 (9, 2019), p.1105-1105

2019

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Progress towards a public chemogenomic set for protein kinases and a call for contributions

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Updated protein domain annotation of the PARP protein family sheds new light on biological function

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Comprehensive characterization of the Published Kinase Inhibitor Set

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

The Intersection of Structural and Chemical Biology - An Essential Synergy

Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

Crystal structure of human RIOK2 bound to a specific inhibitor

Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity

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